Evolution of gut microbiota in psoriatic arthritis treated with IL-17 inhibitor revealed by metagenomics.

IF 3.8 3区 医学 Q1 RHEUMATOLOGY Joint Bone Spine Pub Date : 2025-02-25 DOI:10.1016/j.jbspin.2025.105868
Wei Liu, Yan Geng, Yu Wang, Juan Zhao, Yong Fan, Xiaohui Zhang, Wenhui Xie, Liang Zhang, Zhuoli Zhang
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引用次数: 0

Abstract

Objectives: To explore the evolution of gut microbiota in taxonomy and function in PsA patients during IL-17i treatment.

Methods: Twenty PsA patients treated with secukizumab were included. Fecal samples were collected before treatment (0 mo.), first month (1 mo.) and third month (3mo.) after treatment, and a total of 60 samples were collected. Shotgun metagenomic sequencing was used to detect all fecal samples.

Results: In the 1 mo. and 3 mo. after IL-17i treatment, the disease activity in PsA patients decreased significantly. Compared with 0 mo., α-diversity calculated by Shannon index and Pielou index increased significantly at 1 mo. and 3 mo. after treatment. Microbial genes encoding Carbohydrate Active enZymes (CAZy) tended to be upregulated after treatment. After treatment, Bacteroidota phylum expanded, especially the abundance of Phocaeicola genus increased gradually with the treatment time (P<0.05). The abundance of Phocaeicola genus was positively correlated with the α-diversity. The Polysaccharide Lyases and Carbohydrate Esterases in CAZy were significantly positively correlated with most of species in Phocaeicola genus.

Conclusions: Treatment with IL-17i induces gut microbiota evolution in PsA patients. The key features of this evolution include increased α-diversity, expansion of the Phocaeicola genus, and upregulation of CAZy. Species within the Phocaeicola genus may be the critical bacteria driving this evolution.

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来源期刊
Joint Bone Spine
Joint Bone Spine 医学-风湿病学
CiteScore
4.50
自引率
11.90%
发文量
184
审稿时长
25 days
期刊介绍: Bimonthly e-only international journal, Joint Bone Spine publishes in English original research articles and all the latest advances that deal with disorders affecting the joints, bones, and spine and, more generally, the entire field of rheumatology. All submitted manuscripts to the journal are subjected to rigorous peer review by international experts: under no circumstances does the journal guarantee publication before the editorial board makes its final decision. (Surgical techniques and work focusing specifically on orthopedic surgery are not within the scope of the journal.)Joint Bone Spine is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.
期刊最新文献
Contents Editorial Board Associations of the ALDH2 rs671 polymorphism and alcohol intake with early-onset gout in a Chinese male cohort. Clinical and ultrasonographic predictors of disease activity after TNF-α inhibitor spacing in patients with psoriatic arthritis. Could the anti-modified protein antibody concept help better define seronegative rheumatoid arthritis?
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