Lobectomy for Papillary Thyroid Carcinoma With Minimal Extrathyroidal Extension: Does the Site of Extension Matter?

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-28 DOI:10.1002/hed.28113

Anner Moskovitz, Nir Tsur, Keren Kaminer, Dean Dudkiewicz, Eyal Robenshtok

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Abstract

Background

There is limited data on the recurrence risk following lobectomy in patients with microscopic extrathyroidal extension (mETE) and the significance of the site of mETE.

Methods

A retrospective study on patients treated with thyroid lobectomy between January 2012 and December 2023.

Results

Sixty-seven patients with papillary thyroid carcinoma (PTC) and mETE were included. Two patients (4.66%) experienced disease recurrence during a mean follow-up of 50 months (IQR 18.8–70.3). Twenty-five patients (37.3%) had anterior extension, 28 (41.8%) posterior, and 14 (20.9%) unknown location. Tumors with posterior extension had a higher rate of tall-cell variant (23.1% vs. 12%) and fewer positive surgical margins (22.2% vs. 37.5%). Three non-disease-related deaths occurred during follow-up. No recurrences were noted in patients with anterior mETE.

Conclusion

The recurrence risk after hemithyroidectomy for PTC with mETE was 4.66%, consistent with low-risk disease. Posterior mETE demonstrated a trend of a more aggressive variant and a higher recurrence rate.

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甲状腺乳头状癌最小甲状腺外扩张的肺叶切除术：扩张部位重要吗？

背景：关于显微甲状腺外展（mETE）患者肺叶切除术后复发风险的资料有限，mETE部位的意义也有限。方法：回顾性分析2012年1月至2023年12月甲状腺小叶切除术患者的资料。结果：纳入67例甲状腺乳头状癌（PTC）合并mETE患者。2例（4.66%）患者在平均50个月的随访期间出现疾病复发（IQR 18.8-70.3）。前伸25例（37.3%），后伸28例（41.8%），未知部位14例（20.9%）。后伸肿瘤的高细胞变异率较高（23.1%比12%），阳性切缘较少（22.2%比37.5%）。随访期间发生3例非疾病相关死亡。前路mETE患者无复发。结论：PTC合并mETE的甲状腺切除术后复发风险为4.66%，符合低危性疾病。后侧mETE表现出更具侵袭性的变异趋势和更高的复发率。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.