Takahiro Sawano, Natsuki Suzuki, Kana Takahashi, Yuta Goto, Kazunori Miyashita, Ryo Takeuchi
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引用次数: 0
Abstract
We report an asymmetric allylation of silyl enol ethers derived from α-ketoesters with allylic alcohols by an iridium/chiral (P,olefin)-ligand catalyst. Allylation with a broad range of silyl enol ethers and allylic alcohols formed the allylated products with excellent enantioselectivities. Silyl enol ethers derived from α-diketones as well as α-ketoesters were also compatible with the asymmetric allylation to achieve nearly perfect enantioselectivities. The utility of allylated products bearing an α-ketoester group and an α-diketone group is demonstrated by transformation to valuable functional groups, exemplified by α-aminoester, aldehyde, 2(1H)-quinoxalinone, and quinoxaline.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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