Azin Tavasoli, Oluwakemi K Okwuegbuna, Bin Tang, Jennifer E Iudicello, Asha R Kallianpur, Ronald J Ellis, Scott L Letendre
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引用次数: 0
Abstract
Objective: Neurocognitive impairment in people with HIV (PWH) is associated with erythrocyte indices, which may serve as indicators of iron metabolism, inflammation, and related factors. Erythropoiesis requires iron, regulated by a multifaceted system of peptide hormones, including hepcidin. This study postulated that hepcidin might modify the relationship between erythrocyte indices and neurocognitive performance in PWH.
Methods: Plasma hepcidin and erythrocyte indices were quantified in 88 virally suppressed PWH who underwent comprehensive neurocognitive assessments. Global neurocognitive performance was summarized by global T -scores. Associations of global T -scores with anemia and erythrocyte indices were determined in univariable analyses. To examine the influence of hepcidin on the relationship between neurocognitive performance and erythrocyte indices, we evaluated interactions between these covariates in relation to global T -scores and then performed stratified analyses.
Results: In multivariable analyses, hepcidin detectability interacted with age ( P = 0.007) and mean corpuscular volume (MCV; P = 0.031) in relation to the global T -score. Interactions between anemia and erythrocyte indices on global T -scores were significant (anemia × MCV, P = 0.008; anemia × MCH, P = 0.011). Stratified analyses identified that lower global T -scores were associated with older age ( P = 0.001) and higher MCV ( P = 0.0046) and mean corpuscular hemoglobin (MCH, P = 0.026) only when hepcidin was undetectable. Among the anemic, worse global T -score was associated with higher MCV ( P = 0.001) and MCH ( P = 0.002).
Conclusion: Findings suggest that iron-related factors (hepcidin, anemia, MCV, MCH) and age influence neurocognitive health. This cross-sectional study underscores hepcidin as an effect modifier in the associations of erythrocyte indices, anemia, and age with neurocognitive function in PWH.
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Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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