Anaplastic thyroid carcinoma: interplay of predictive factors, treatment challenges, and survival insights.

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM Expert Review of Endocrinology & Metabolism Pub Date : 2025-03-01 Epub Date: 2025-02-28 DOI:10.1080/17446651.2025.2467660
Asad Ullah, Kavita Prasad, Asim Ahmed, Kue Tylor Lee, Abdul Qahar Khan Yasinzai, Asif Iqbal, Amir Humza Sohail, Dauod Arif, Sana Jogezai, Luis Brandi, Nabin Raj Karki, Marjan Khan, Agha Wali, Hritvik Jain, Nagla Abdel Karim
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引用次数: 0

Abstract

Objective: Anaplastic thyroid carcinoma (ATC) is a rare and aggressive thyroid neoplasm. This study is the largest to date and aims to provide the most up-to-date analysis of demographics and clinicopathological factors of ATC.

Methods: Data for this study were extracted from the Surveillance, Epidemiology, and End Results (SEER) database.

Results: A total of 1,769 cases of ATC were included with a median age at diagnosis was 71 years, and 59% were females. The most common site of metastasis was the lung (40.7%). The majority of patients underwent combination therapy (surgery with adjuvant chemoradiation) (19.2%). The 5-year OS was 7.3% (95% C.I. 6.6-8.0). The 5-year CSS was 11.8% (95% C.I. 10.8-12.8). The highest 5-year survival was observed with combination therapy (surgery with adjuvant chemoradiation) at 20.9%. Multivariable analysis revealed that age >60 years, Asian/Pacific Islander, >2 cm tumor size, and metastatic disease were independent risk factors.

Conclusions: ATC is an uncommon tumor that mainly affects Caucasian females in their 70s. Older age, Asian/Pacific Islander race, and larger tumor size (>2 cm) were also associated with a worse prognosis. For better comprehension of pathogenesis, prospective clinical trials should include patients from all ethnicities, gender, and genomic analysis of ATC.

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Expert Review of Endocrinology & Metabolism
Expert Review of Endocrinology & Metabolism ENDOCRINOLOGY & METABOLISM-
CiteScore
4.80
自引率
0.00%
发文量
44
期刊介绍: Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.
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