Molecular Mechanisms of ARD1 in Tumors

IF 3.1 2区医学 Q2 ONCOLOGY Cancer Medicine Pub Date : 2025-03-03 DOI:10.1002/cam4.70708

Chunjiao Yu, Hongtao Lei, Xuefei Hou, Shan Yan

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Abstract

Introduction

Arrest-deficient protein 1 (ARD1) is an acetyltransferase that acetylates the N-terminal amino acids and internal lysine residues of proteins. It plays a crucial role in various cellular processes. The significance of ARD1 in tumor development has become increasingly evident in recent years.

Methods

This review analyzes the regulatory role of ARD1 in tumor progression by examining its involvement in processes such as cell cycle regulation, cell proliferation, metastasis, apoptosis, and autophagy. Additionally, we discuss the expression patterns and molecular mechanisms of ARD1 in different types of cancer.

Results

Elevated levels of ARD1 have been reported in several cancer types. Its increased expression is associated with various tumor characteristics, suggesting it may serve as a potential prognostic biomarker. Furthermore, ARD1 could be targeted for the development of novel cancer therapies.

Conclusion

Understanding the role of ARD1 in tumor biology provides valuable insights into potential therapeutic targets and biomarkers for cancer treatment. This review highlights the advances in ARD1-related research and suggests that it may be a promising avenue for improving cancer prognosis and treatment strategies.

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ARD1在肿瘤中的分子机制

ARD1是一种乙酰转移酶，可使蛋白质的n端氨基酸和内部赖氨酸残基乙酰化。它在各种细胞过程中起着至关重要的作用。近年来，ARD1在肿瘤发生发展中的意义越来越明显。方法从细胞周期调节、细胞增殖、转移、凋亡、自噬等方面分析ARD1在肿瘤进展中的调控作用。此外，我们还讨论了ARD1在不同类型癌症中的表达模式和分子机制。结果ARD1水平升高已在几种癌症类型中被报道。它的表达增加与多种肿瘤特征相关，这表明它可能作为一种潜在的预后生物标志物。此外，ARD1可能成为开发新型癌症疗法的靶点。结论了解ARD1在肿瘤生物学中的作用，为癌症治疗的潜在治疗靶点和生物标志物提供了有价值的见解。本文综述了ard1相关研究的进展，并提示它可能是改善癌症预后和治疗策略的有希望的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.