The role of TREM2 in myelin sheath dynamics: A comprehensive perspective from physiology to pathology

IF 6.1 2区医学 Q1 NEUROSCIENCES Progress in Neurobiology Pub Date : 2025-04-01 Epub Date: 2025-02-26 DOI:10.1016/j.pneurobio.2025.102732

Xinwei Que , Tongtong Zhang , Xueyu Liu , Yunsi Yin , Xinyi Xia , Ping Gong , Weiyi Song , Qi Qin , Zhi-Qing David Xu , Yi Tang

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Abstract

Demyelinating disorders, characterizing by the loss of myelin integrity, present significant challenges due to their impact on neurological function and lack of effective treatments. Understanding the mechanisms underlying myelin damage is crucial for developing therapeutic strategies. Triggering receptor expressed on myeloid cells 2 (TREM2), a pivotal immune receptor predominantly found on microglial cells, plays essential roles in phagocytosis and lipid metabolism, vital processes in neuroinflammation and immune regulation. Emerging evidence indicates a close relationship between TREM2 and various aspects of myelin sheath dynamics, including maintenance, response to damage, and regeneration. This review provides a comprehensive discussion of TREM2's influence on myelin physiology and pathology, highlighting its therapeutic potential and putative mechanisms in the progression of demyelinating disorders.

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TREM2在髓鞘动力学中的作用：从生理学到病理学的综合视角。

脱髓鞘疾病以髓鞘完整性丧失为特征，由于对神经功能的影响和缺乏有效的治疗方法，这种疾病带来了巨大的挑战。了解髓鞘损伤的内在机制对于制定治疗策略至关重要。髓系细胞上表达的触发受体 2（TREM2）是一种主要存在于小胶质细胞上的关键免疫受体，在吞噬和脂质代谢过程中发挥着至关重要的作用，而吞噬和脂质代谢是神经炎症和免疫调节的重要过程。新的证据表明，TREM2 与髓鞘动态的各个方面（包括维持、对损伤的反应和再生）都有密切关系。本综述全面论述了 TREM2 对髓鞘生理和病理的影响，强调了 TREM2 在脱髓鞘疾病进展过程中的治疗潜力和假定机制。

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来源期刊

Progress in Neurobiology 医学-神经科学

CiteScore

12.80

自引率

1.50%

发文量

107

审稿时长

33 days

期刊介绍： Progress in Neurobiology is an international journal that publishes groundbreaking original research, comprehensive review articles and opinion pieces written by leading researchers. The journal welcomes contributions from the broad field of neuroscience that apply neurophysiological, biochemical, pharmacological, molecular biological, anatomical, computational and behavioral analyses to problems of molecular, cellular, developmental, systems, and clinical neuroscience.