{"title":"Nickel promoted tandem C-N cross-coupling reaction in water: The synthesis of 2-azido-benzimidazoles and 2-iodoarylcyanamides","authors":"V.V.K. Vasu Juthiga , Megha Balha , Ramana Tamminana","doi":"10.1016/j.molstruc.2025.141857","DOIUrl":null,"url":null,"abstract":"<div><div>The article describes an efficient method for the synthesis of 2-azidobenzimidazole employing nickel catalyst and DL-alpha-tocopherol methoxypolyethylene glycol succinate solution (TPGS-750-M) as a biodegradable surfactant in water through tandem intra-and inter molecular <em>C-N</em> bond formation. Using of water as a reaction medium and TPGS-750-M as a surfactant obviates the necessity for organic solvents, thereby enhancing the environmental sustainability of the synthesis. Further, this article also accomplishes an approach for aryl cyanamides at room temperature under green conditions. Spectroscopic techniques, including <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and IR characterised the target products.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1334 ","pages":"Article 141857"},"PeriodicalIF":4.0000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Structure","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022286025005435","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The article describes an efficient method for the synthesis of 2-azidobenzimidazole employing nickel catalyst and DL-alpha-tocopherol methoxypolyethylene glycol succinate solution (TPGS-750-M) as a biodegradable surfactant in water through tandem intra-and inter molecular C-N bond formation. Using of water as a reaction medium and TPGS-750-M as a surfactant obviates the necessity for organic solvents, thereby enhancing the environmental sustainability of the synthesis. Further, this article also accomplishes an approach for aryl cyanamides at room temperature under green conditions. Spectroscopic techniques, including 1H-NMR, 13C-NMR, and IR characterised the target products.
期刊介绍：
The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including:
• Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.)
• Chemical intermediates
• Molecules in excited states
• Biological molecules
• Polymers.
The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example:
• Infrared spectroscopy (mid, far, near)
• Raman spectroscopy and non-linear Raman methods (CARS, etc.)
• Electronic absorption spectroscopy
• Optical rotatory dispersion and circular dichroism
• Fluorescence and phosphorescence techniques
• Electron spectroscopies (PES, XPS), EXAFS, etc.
• Microwave spectroscopy
• Electron diffraction
• NMR and ESR spectroscopies
• Mössbauer spectroscopy
• X-ray crystallography
• Charge Density Analyses
• Computational Studies (supplementing experimental methods)
We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
