{"title":"Nickel promoted tandem C-N cross-coupling reaction in water: The synthesis of 2-azido-benzimidazoles and 2-iodoarylcyanamides","authors":"V.V.K. Vasu Juthiga , Megha Balha , Ramana Tamminana","doi":"10.1016/j.molstruc.2025.141857","DOIUrl":null,"url":null,"abstract":"<div><div>The article describes an efficient method for the synthesis of 2-azidobenzimidazole employing nickel catalyst and DL-alpha-tocopherol methoxypolyethylene glycol succinate solution (TPGS-750-M) as a biodegradable surfactant in water through tandem intra-and inter molecular <em>C-N</em> bond formation. Using of water as a reaction medium and TPGS-750-M as a surfactant obviates the necessity for organic solvents, thereby enhancing the environmental sustainability of the synthesis. Further, this article also accomplishes an approach for aryl cyanamides at room temperature under green conditions. Spectroscopic techniques, including <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and IR characterised the target products.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1334 ","pages":"Article 141857"},"PeriodicalIF":4.7000,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Structure","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022286025005435","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The article describes an efficient method for the synthesis of 2-azidobenzimidazole employing nickel catalyst and DL-alpha-tocopherol methoxypolyethylene glycol succinate solution (TPGS-750-M) as a biodegradable surfactant in water through tandem intra-and inter molecular C-N bond formation. Using of water as a reaction medium and TPGS-750-M as a surfactant obviates the necessity for organic solvents, thereby enhancing the environmental sustainability of the synthesis. Further, this article also accomplishes an approach for aryl cyanamides at room temperature under green conditions. Spectroscopic techniques, including 1H-NMR, 13C-NMR, and IR characterised the target products.
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