Visible Light-Induced Arylsulfonylation/Cyclization Reactions for the Synthesis of Thiochromane 1,1-dioxide

IF 3.3 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemistry - An Asian Journal Pub Date : 2025-03-02 DOI:10.1002/asia.202401940
Shan Li, Yang Liu, Ya-Qian Shi, Jia-Xin Ning, Xiu-Juan Li, Yu-Fan Zhang, Zi-Qun Zhu, Hong-Li Huang, Na Ma, Fei Gao
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Abstract

Simple operation, easily accessible starting materials, and short syntheses of the privileged scaffold thiochromane 1,1-dioxide that widely exist in bioactive molecules was achieved by photocatalytic divergent cyclization of α-allyl-β-ketosulfones with arylsulfonyl chlorides. Optimization and scope and limitations of this short and general pathway are described. The methodology provides an efficient strategy for the construction of a wide variety of thiochromane 1,1-dioxide derivatives.

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可见光诱导芳基磺酰化/环化反应合成1,1-二硫代铬醚。
通过光催化α-烯丙基-β-酮砜与芳基磺酰氯的分散环化反应,获得了广泛存在于生物活性分子中的优势支架硫代铬烷1,1-二氧化物,其合成时间短,操作简单,起始原料容易获取。描述了这种短而通用的途径的优化、范围和限制。该方法为构建多种硫代氯甲烷1,1-二氧化物衍生物提供了一种有效的策略。
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来源期刊
Chemistry - An Asian Journal
Chemistry - An Asian Journal 化学-化学综合
CiteScore
7.00
自引率
2.40%
发文量
535
审稿时长
1.3 months
期刊介绍: Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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