C3-Dominant Infection Related Crescentic Glomerulonephritis.

Abstract

Infection related glomerulonephritis and more specifically streptococcal glomerulonephritis is a rare disease in adults, and so is C3 glomerulonephritis. It has been recognized that a clinical and morphological overlap between these two entities exists. We present a case of a 59-year-old man with previous treated HIV infection with virological response, treated hepatitis b infection, treated syphilis and non-Hodgkin lymphoma in remission; presenting and acute sore throat with high ASO titers two weeks before a rapidly progressive glomerulonephritis requiring dialysis since presentation; biopsy showed acute diffuse and proliferative glomerulonephritis with crescentic pattern with exclusive C3 staining. It was considered an acute crescentic glomerulonephritis meeting criteria for infection related glomerulonephritis but also had criteria for C3 glomerulonephritis.