A Bibliometric and Visual Analysis of Oliceridine Research (2013-2024).

IF 5.1 2区医学 Q1 CHEMISTRY, MEDICINAL Drug Design, Development and Therapy Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI:10.2147/DDDT.S497186

Cheng Song, Xinxing Huang, Nianping Chen, Qiliang Song, Yuanli Qiu

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引用次数: 0

Abstract

Purpose: To explore and analyze the current research progress, hotspots, and future trends in oliceridine research using bibliometric methods.

Patients and methods: We searched the Web of Science (WOS) database utilizing the keywords TS = ("oliceridine*" OR "TRV 130*" OR "TRV-130*" OR "olinvyk*" OR "TRV130*" OR "C22H31CIN2O2S*") for relevant research literature on oliceridine from its inception to June 16, 2024. Bibliometric methods were applied, and analysis software such as VOSviewer and CiteSpace were used to visualize the publication timeline, authors, countries and regions, keywords, sources of literature, research hotspots, and co-cited documents related to oliceridine. Co-occurrence and aggregation analyses were conducted, and maps relevant to institutional cooperation were generated.

Results: A total of 151 relevant articles were retrieved and included in the final analysis. Most articles were published between 2020 and 2021. The United States has the highest number of publications and citations in this field. Molecular structure development is a pivotal point in this field. Research hotspots were diverse, including acute pain, opioid receptors, β-arrestin, postoperative pain, therapeutic window, respiratory depression, clinical trials, and chronic pain.

Conclusion: Oliceridine, a newly developed analgesic, has garnered global interest. The USA is a leading contributor to this field. Recent research has shifted from basic studies to clinical practice.

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2013-2024年橄榄碱研究的文献计量与视觉分析。

目的：运用文献计量学方法，探讨和分析当前橄榄苷的研究进展、研究热点及未来趋势。患者和方法：我们在Web of Science （WOS）数据库中检索关键词TS =（“oliceridine*”OR“TRV130*”OR“TRV-130*”OR“olinvyk*”OR“TRV130*”OR“C22H31CIN2O2S*”），检索从oliceridine问世至2024年6月16日的相关研究文献。采用文献计量学方法，利用VOSviewer、CiteSpace等分析软件对与联机联机相关的文献发表时间、作者、国家和地区、关键词、文献来源、研究热点、共被引文献进行可视化分析。进行了共现和聚合分析，并生成了与机构合作相关的地图。结果：共检索到151篇相关文献并纳入最终分析。大多数文章发表于2020年至2021年之间。美国在这一领域的出版物和引用数量最多。分子结构的发展是这一领域的一个关键点。研究热点多样，包括急性疼痛、阿片受体、β-抑制素、术后疼痛、治疗窗口、呼吸抑制、临床试验、慢性疼痛等。结论：橄榄碱是一种新开发的镇痛药，已引起全球关注。美国是这一领域的主要贡献者。最近的研究已经从基础研究转向临床实践。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.