Global burden of reported lower respiratory system fungal infection.

IF 4.8 2区医学 Q2 IMMUNOLOGY Frontiers in Cellular and Infection Microbiology Pub Date : 2025-02-14 eCollection Date: 2025-01-01 DOI:10.3389/fcimb.2025.1542922

Zheng Wang, Mengshu Pan, Jie Zhu

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Abstract

Background: The epidemiological trend of lower respiratory tract fungal infections remains unclear. This study aims to quantify the global burden of these infections from 1990 to 2021 using data from the Global Burden of Disease Study 2021.

Methods: Data were analyzed at global, regional, and national levels, considering factors such as age, gender, region, and socio-demographic index (SDI). Key indicators included age-standardized disability-adjusted life-year (ASDR) and age-standardized mortality rates (ASMR).

Results: On a global scale, the burden of lower respiratory fungal infections decreased significantly from 1990 to 2021, with a decline in mortality rates. Regionally, substantial disparities were observed among the 21 geographic super-regions. Nationally, Argentina experienced the greatest increase in ASDR and ASMR, while Finland showed the largest decrease, with average annual percentage changes (AAPC) below -5 for both indicators. Sex-based analysis revealed a notably higher burden in males compared to females. ASDR and ASMR were negatively correlated with SDI in most regions.

Conclusion: Although the global burden of lower respiratory tract fungal infections has decreased, it remains a substantial public health issue, particularly in low-SDI regions. There is an urgent need to implement targeted preventive measures to address this ongoing challenge.

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报告的下呼吸道真菌感染的全球负担。

背景：下呼吸道真菌感染的流行趋势尚不清楚。本研究旨在利用2021年全球疾病负担研究的数据，量化1990年至2021年这些感染的全球负担。方法：考虑年龄、性别、地区和社会人口指数（SDI）等因素，对全球、地区和国家层面的数据进行分析。主要指标包括年龄标准化残疾调整生命年（ASDR）和年龄标准化死亡率（ASMR）。结果：在全球范围内，从1990年到2021年，下呼吸道真菌感染的负担显著下降，死亡率下降。从区域来看，21个地理超级区域之间存在巨大差异。在全国范围内，阿根廷的ASDR和ASMR增幅最大，而芬兰的降幅最大，两项指标的年均百分比变化（AAPC）均低于-5。基于性别的分析显示，男性的负担明显高于女性。大部分地区的ASDR和ASMR与SDI呈负相关。结论：尽管全球下呼吸道真菌感染负担有所下降，但它仍然是一个重大的公共卫生问题，特别是在低sdi地区。迫切需要实施有针对性的预防措施，以应对这一持续的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.