Liyuan Yao , Aikebaier Jumai , Xiancai Li , Shaohua Chen , Bailin Li , Sheng-Xiang Qiu
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引用次数: 0
Abstract
Three new phthalide derivatives, denominated Cajanthalides A, B and C (1–3), were identified from the leaves of Cajanus cajan. Their structures were meticulously elucidated through comprehensive analysis utilizing UV, IR, NMR (1D and 2D), HRESIMS, chiral analysis and DP4+ analysis. Notably, these new phthalide derivatives are present in racemic forms, with compounds 2 and 3 sharing identical planar structures. A plausible biogenetic pathway is proposed to account for the biosynthesis of compounds 1–3. Biological evaluation revealed that compound 2 exhibited moderate antifungal activity against C. neoformans, C. albicans and M. furfur with MIC values of 40 μg/mL.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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