Effects of Deinorgestrel Treatment of Endometriosis on Ovarian Function, Inflammatory Factors, and Pregnancy Rate in Patients.

Abstract

Objective: To compare the effects of deinorgestrel and Guizhi Fuling Capsules on ovarian function, inflammatory variables, and the rate of conception in clients receiving endometriosis treatment.

Methods: Ninety endometriosis patients were divided into the control and test groups. Patients in the control group received oral treatment with Guizhi Fuling Capsules, and those in the test group received oral treatment with Deinorgestrel Tablets.

Results: Compared with the control group, the overall effective therapy rate in the test group was significantly increased. Following the intervention, the test group experienced a considerably larger decrease in interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels than the control group. The visual analog scale (VAS ) values for dysmenorrhea, dyspareunia, and non-menstrual lower abdomen discomfort were all considerably lower after therapy than those before therapy. In comparison to the control group, the VAS grades for dysmenorrhea, non-menstrual lower abdomen pain, and sexual intercourse discomfort showed a substantial increase in the test group. Compared with the control group, the 1-year cumulative pregnancy rate in the test group was significant increase in the test group (42.22% (19/45) vs. 64.44% (29/45)).

Conclusion: Denogestone significantly alleviates clinical symptoms and body's inflammatory state of Endometriosis patients, without ovarian function damage.