Gerobiotics: Exploring the Potential and Limitations of Repurposing Probiotics in Addressing Aging Hallmarks and Chronic Diseases.

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Probiotics and Antimicrobial Proteins Pub Date : 2026-01-01 Epub Date: 2025-03-03 DOI:10.1007/s12602-025-10501-w

A G M Sofi Uddin Mahamud, Ishtiak Ahammed Tanvir, Md Ehsanul Kabir, Ismam Samonty, Md Anamul Hasan Chowdhury, Md Ashikur Rahman

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Abstract

As unhealthy aging continues to rise globally, there is a pressing need for effective strategies to promote healthy aging, extend health span, and address aging-related complications. Gerobiotics, an emerging concept in geroscience, offers a novel approach to repurposing selective probiotics, postbiotics, and parabiotics to modulate key aging processes and enhance systemic health. This review explores recent advancements in gerobiotics research, focusing on their role in targeting aging hallmarks, regulating longevity-associated pathways, and reducing risks of multiple age-related chronic conditions. Despite their promise, significant challenges remain, including optimizing formulations, ensuring safety and efficacy across diverse populations, and achieving successful clinical translation. Addressing these gaps through rigorous research, well-designed clinical trials, and advanced biotechnologies can establish gerobiotics as a transformative intervention for healthy aging and chronic disease prevention.

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老年生物学：探索益生菌在解决衰老特征和慢性疾病方面的潜力和局限性。

随着全球不健康老龄化的持续增加，迫切需要有效的策略来促进健康老龄化，延长健康寿命，并解决与老龄化相关的并发症。老年生物学是老年科学中的一个新兴概念，它提供了一种新的方法来重新利用选择性益生菌、后益生菌和共生菌来调节关键的衰老过程和增强全身健康。本文综述了近年来老年生物制剂的研究进展，重点介绍了它们在针对衰老特征、调节长寿相关途径和降低多种年龄相关慢性疾病风险方面的作用。尽管它们有希望，但仍然存在重大挑战，包括优化配方，确保不同人群的安全性和有效性，以及实现成功的临床转化。通过严谨的研究、精心设计的临床试验和先进的生物技术来解决这些差距，可以将老年生物制剂确立为健康老龄化和慢性疾病预防的变革性干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY

CiteScore

11.30

自引率

6.10%

发文量

140

期刊介绍： Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.