CCL11 (Eotaxin) Promotes the Advancement of Aging-Related Cardiovascular Diseases.

IF 1.3 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Reviews in cardiovascular medicine Pub Date : 2025-02-13 eCollection Date: 2025-02-01 DOI:10.31083/RCM26020

Tanwei Zhang, Yanhong Huang, Xinmeng Ji, Teng Wu, Pingxi Xiao

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Abstract

Aging-related diseases, such as cardiovascular diseases (CVDs), neurodegeneration, cancer, etc., have become important factors that threaten the lifespans of older individuals. A chronic inflammatory response is closely related to aging-related diseases. Establishing inflammatory aging clock (iAGE, deep-learning methods on blood immune biomarkers to construct a metric for age-related chronic inflammation) successfully predicted the positive correlation between several factors, including serum C-C-motif chemokine ligand 11 (CCL11) and aging-related diseases. Recently, the role and mechanism of CCL11, an eosinophilic chemokine, in neurodegenerative diseases have been widely reported. Additionally, many research studies have shown a positive correlation with CVDs, but the underlying mechanism remains unknown. This review focuses on the relationship between chronic inflammation and aging. The role of CCL11 will be discussed and summarized in relation to aging-related diseases, especially CVDs.

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CCL11（Eotaxin）促进衰老相关心血管疾病的发展

与衰老有关的疾病，如心血管疾病、神经退行性疾病、癌症等，已成为威胁老年人寿命的重要因素。慢性炎症反应与衰老相关疾病密切相关。建立炎症老化时钟（iAGE，利用深度学习方法对血液免疫生物标志物构建年龄相关慢性炎症指标）成功预测了血清c - c基序趋化因子配体11 （CCL11）等多个因素与衰老相关疾病之间的正相关关系。近年来，嗜酸性趋化因子CCL11在神经退行性疾病中的作用和机制被广泛报道。此外，许多研究已经表明与心血管疾病呈正相关，但其潜在机制尚不清楚。本文就慢性炎症与衰老的关系作一综述。本文将讨论和总结CCL11在衰老相关疾病，特别是心血管疾病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews in cardiovascular medicine 医学-心血管系统

CiteScore

2.70

自引率

3.70%

发文量

377

审稿时长

1 months

期刊介绍： RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.