miR-135b: A Potential Biomarker for Pathological Diagnosis and Biological Therapy.

IF 4.8 2区生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2025-03-01 DOI:10.1002/wrna.70002

Dezhi Yan, Qingliu He, Chunjian Wang, Tian Li, Xueping Yi, Haisheng Yu, Wenfei Wu, Hanyun Yang, Wenzhao Wang, Liang Ma

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Abstract

MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs found in eukaryotes with post-transcriptional regulatory functions. A variety of miRNAs is differentially expressed in cancer tissues and thus can be used as biomarkers. microRNA-135b-5p (miR-135b) has been shown to be involved in the pathological processes of a variety of neoplastic and non-neoplastic diseases. Under different conditions, miR-135b has different tumor suppressive and carcinogenic effects. miR-135b regulates the development of cancer, including metabolism, proliferation, apoptosis, invasion, fibrosis, angiogenesis, immunomodulation, and drug resistance. miR-135b can be used as a new biomarker for tumor diagnosis and prognosis, which has the potential for clinical guidance. This article reviews the relevant research on miR-135B in the field of tumors, including the biogenesis background of miR-135b, the expression of miR-135b in tumors, and the related targets and signaling pathways of miR-135b mediating tumor progression in order to sort out and explore the clinical transformation value of miR-135b.

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miR-135b：病理诊断和生物治疗的潜在生物标志物

MicroRNAs （miRNAs）是一类存在于真核生物中具有转录后调控功能的内源性非编码rna。多种mirna在癌症组织中存在差异表达，因此可以作为生物标志物。microRNA-135b-5p （miR-135b）已被证明参与多种肿瘤性和非肿瘤性疾病的病理过程。在不同条件下，miR-135b具有不同的抑瘤和致癌作用。miR-135b调控肿瘤的发展，包括代谢、增殖、凋亡、侵袭、纤维化、血管生成、免疫调节和耐药。miR-135b可作为肿瘤诊断和预后的新生物标志物，具有指导临床的潜力。本文综述了miR-135B在肿瘤领域的相关研究，包括miR-135B的生物发生背景、miR-135B在肿瘤中的表达、miR-135B介导肿瘤进展的相关靶点和信号通路，以梳理和探讨miR-135B的临床转化价值。

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来源期刊

Wiley Interdisciplinary Reviews: RNA CELL BIOLOGY-

CiteScore

14.80

自引率

4.10%

发文量

审稿时长

6-12 weeks

期刊介绍： WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.