Nanourchin-like Uricase-Poly(L-proline) Conjugate with Retained Enzymatic Activity, Mitigated Immunogenicity, and Sustained Efficacy Upon Repeated Administrations
Ruichi Zhao, Yangming Zhang, Banlai Ruan, Hairuo Zhang, Niannian Lv, Jiayi Li, Yuhe R. Yang, Xiaozhou Luo, Hua Lu
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引用次数: 0
Abstract
Poly(L-proline) conjugated uricase was facilely produced via a grafting-from approach, which showed mitigated immunogenicity and preserved activity in vivo after repeated injections.
期刊介绍：
Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.
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