Host ecology and phylogeny shape the temporal dynamics of social bee viromes

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Nature Communications Pub Date : 2025-03-05 DOI:10.1038/s41467-025-57314-7

Vincent Doublet, Toby D. Doyle, Claire Carvell, Mark J. F. Brown, Lena Wilfert

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Abstract

The composition of viral communities (i.e. viromes) can be dynamic and complex. Co-evolution may lead to virome host-specificity. However, eco-evolutionary factors may influence virome dynamics in wild host communities, potentially leading to disease emergence. Social bees are relevant models to address the drivers of virome composition: these important pollinators form multi-species assemblages, with high niche overlap and strong seasonality in their biotic interactions. We applied a microbial community approach to disentangle the role of host phylogeny and host ecology in shaping bee viromes, combining plant-pollinator networks with meta-transcriptomics, and small interfering RNAs as proxies for viral replication in pollinators and pollen. We identified over a hundred insect and plant viral sequences from ca. 4500 insect pollinator samples across three time points in one year. While host genetic distance drives the distribution of bee viruses, we find that plant-pollinator interactions and phenology drive plant virus communities collected by bees. This reveals the opportunities for virus spread in the bee assemblage. However, we show that transmission to multiple hosts is only realized for a fraction of insect viruses, with even fewer found to be actively replicating in multiple species, including the particularly virulent multi-host acute bee paralysis virus.

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宿主生态和系统发育塑造了社会蜜蜂病毒群的时间动态

病毒群落（即病毒组）的组成可以是动态的和复杂的。共同进化可能导致病毒体宿主特异性。然而，生态进化因素可能影响野生宿主群落的病毒动力学，可能导致疾病的出现。群居蜜蜂是解决病毒组成驱动因素的相关模型：这些重要的传粉媒介形成多物种组合，在其生物相互作用中具有高度的生态位重叠和强烈的季节性。我们应用微生物群落方法来解开寄主系统发育和寄主生态在形成蜜蜂病毒组中的作用，将植物-传粉媒介网络与元转录组学结合起来，并将小干扰rna作为传粉媒介和花粉中病毒复制的代理。我们在一年的三个时间点从大约4500个昆虫传粉者样本中鉴定了100多个昆虫和植物病毒序列。虽然寄主遗传距离驱动蜜蜂病毒的分布，但我们发现植物与传粉者的相互作用和物候驱动蜜蜂收集的植物病毒群落。这揭示了病毒在蜜蜂群体中传播的机会。然而，我们发现只有一小部分昆虫病毒能够传播到多个宿主，甚至更少的昆虫病毒能够在多个物种中积极复制，包括特别致命的多宿主急性蜜蜂麻痹病毒。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.