{"title":"Differences in the absorption and metabolism of vitamin D2, vitamin D3, and 25 hydroxyvitamin D","authors":"James C. Fleet","doi":"10.1016/j.jsbmb.2025.106718","DOIUrl":null,"url":null,"abstract":"<div><div>A challenge for public health is to make recommendations for the intake of vitamin D to optimize health and prevent disease. Vitamin D supplementation can be accomplished using vitamin D<sub>2</sub> (from fungi), vitamin D<sub>3</sub> (from vertebrate sources), or as the prehormone 25 hydroxyvitamin D<sub>3</sub> (25OHD<sub>3</sub>). While these three sources are generally effective for raising and maintaining vitamin D status, their effect is not identical. This review will summarize the differences between these molecules in their routes of absorption, their metabolism, degradation, and molecular function.</div></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"249 ","pages":"Article 106718"},"PeriodicalIF":2.7000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Steroid Biochemistry and Molecular Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0960076025000469","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A challenge for public health is to make recommendations for the intake of vitamin D to optimize health and prevent disease. Vitamin D supplementation can be accomplished using vitamin D2 (from fungi), vitamin D3 (from vertebrate sources), or as the prehormone 25 hydroxyvitamin D3 (25OHD3). While these three sources are generally effective for raising and maintaining vitamin D status, their effect is not identical. This review will summarize the differences between these molecules in their routes of absorption, their metabolism, degradation, and molecular function.
期刊介绍：
The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental and theoretical developments in areas related to steroids including vitamin D, lipids and their metabolomics. The Journal publishes a variety of contributions, including original articles, general and focused reviews, and rapid communications (brief articles of particular interest and clear novelty). Selected cutting-edge topics will be addressed in Special Issues managed by Guest Editors. Special Issues will contain both commissioned reviews and original research papers to provide comprehensive coverage of specific topics, and all submissions will undergo rigorous peer-review prior to publication.
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