{"title":"Synthesis of benzimidazo[1,2-c]quinazolin-6(5H)-one derivatives via copper-mediated C–H isocyanatation of 2-arylbenzimidazoles","authors":"Ali Nasirpour, Zarrin Ghasemi","doi":"10.1016/j.tet.2025.134569","DOIUrl":null,"url":null,"abstract":"<div><div>An efficient protocol is disclosed for the synthesis of benzimidazo[1,2-<em>c</em>]quinazolin-6(5<em>H</em>)-ones utilizing an atom-economical C–H functionalization method. Copper-mediated isocyanatation of the aryl ring of the prepared 2-arylbenzimidazole derivatives, followed with intramolecular cyclization reaction resulted in the desired products. We diversified and purified the products without chromatography.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"177 ","pages":"Article 134569"},"PeriodicalIF":2.2000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402025001255","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
An efficient protocol is disclosed for the synthesis of benzimidazo[1,2-c]quinazolin-6(5H)-ones utilizing an atom-economical C–H functionalization method. Copper-mediated isocyanatation of the aryl ring of the prepared 2-arylbenzimidazole derivatives, followed with intramolecular cyclization reaction resulted in the desired products. We diversified and purified the products without chromatography.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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