B-waves in noninvasive capacitance signal correlate with B-waves in ICP

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY Acta Neurochirurgica Pub Date : 2025-03-06 DOI:10.1007/s00701-025-06461-3

Andreas Spiegelberg, Andrea Boraschi, Ramy Amirah, Katharina Wolf, Mukesch Shah, Laura Krismer, Jürgen Beck, Vartan Kurtcuoglu

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Abstract

Background

Analysis of B-waves in overnight intracranial pressure (ICP) recordings used to be an important element in the diagnosis of normal pressure hydrocephalus (NPH). Here, we tested the hypothesis that equivalents to B-waves can be detected and quantified in a noninvasively measured electric capacitance signal termed W.

Methods

We measured ICP and W in a cohort of 15 patients with suspected diagnosis of NPH or spontaneous intracranial hypotension during infusion testing, identifying B-waves in both signals by wave-template matching in the time domain.

Results

We found very strong correlation between the duration of B-waves in ICP and W (R² = 0.86, p < 10^–6), and weak correlation between the average B-wave amplitudes in ICP and W (R = 0.34, p = 0.02).

Conclusions

The concurrent presence of B-waves in the signals suggests that vasogenic activity of cerebral autoregulation is reflected in W. The weaker correlation of amplitudes may be attributed to W being an indirect measure of cranial volume composition, whereas ICP is a measure of pressure, with the two linked by the non-linear craniospinal pressure-volume relation that varies between patients. Analysis of the noninvasively acquired W signal should be evaluated as a triage tool for patients with NPH and other disorders characterized by reduced compliance.

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无创电容信号中的b波与ICP中的b波相关

背景：夜间颅内压（ICP）记录的b波分析曾经是诊断正常压力性脑积水（NPH）的重要因素。在这里，我们验证了一种假设，即等效的b波可以在无创性测量的电容信号中被检测到并量化。方法我们在输液测试中测量了15例疑似诊断为NPH或自发性颅内低血压的患者的ICP和W，通过在时域中进行波模板匹配来识别这两个信号中的b波。结果颅内压b波持续时间与W呈极强相关（R2 = 0.86, p < 10-6），颅内压b波平均振幅与W呈弱相关（R = 0.34, p = 0.02）。结论信号中同时存在的b波表明，脑自调节的血管生成活动在W中得到了反映。振幅相关性较弱可能是由于W是颅体积组成的间接测量，而ICP是压力的测量，两者之间的非线性颅脊髓压力-容积关系因患者而异。对于NPH和其他以依从性降低为特征的疾病患者，应评估无创获取的W信号作为分诊工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.