Ferroptosis of T cell in inflammation and tumour immunity

IF 6.8 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Translational Medicine Pub Date : 2025-03-05 DOI:10.1002/ctm2.70253

Xueli Xia, Haisheng Wu, Yuxuan Chen, Huiyong Peng, Shengjun Wang

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Abstract

Ferroptosis is an innovative concept defined as a distinct programmed cell death mode regulated by iron-dependent lipid peroxidation accumulation. This process is governed by numerous energy metabolites such as fatty acids, amino acids and glucose, as well as iron homeostasis. In recent years, increasing studies have been devoted to the crucial effects of ferroptosis in immune cells during the pathogenesis of diseases such as infections, tumours and autoimmune disorders. This review summarises the latest advancements in T-cell ferroptosis, addresses the key components and mechanism of ferroptosis in T cells during inflammatory conditions and tumour progression, and highlights the potential target for treating related diseases.

Key points

Ferroptosis-related mechanisms significantly affect the biology of CD4⁺ T-cell subsets and are further involved in inflammatory diseases.
Crosstalk between CD8⁺ T cells and tumour cells induces ferroptosis in the tumour microenvironment.
Glutathione peroxidase 4 loss promotes regulatory T-cell ferroptosis to enhance anti-tumour immunity.

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T细胞铁下垂在炎症和肿瘤免疫中的作用

铁死亡是一个创新的概念，被定义为一种独特的程序性细胞死亡模式，由铁依赖性脂质过氧化积累调节。这个过程是由许多能量代谢物控制的，如脂肪酸、氨基酸和葡萄糖，以及铁的体内平衡。近年来，越来越多的研究致力于在感染、肿瘤和自身免疫性疾病等疾病的发病过程中，铁下垂在免疫细胞中的关键作用。本文综述了T细胞铁下垂的最新进展，阐述了炎症和肿瘤进展过程中T细胞铁下垂的关键成分和机制，并强调了治疗相关疾病的潜在靶点。凋亡相关机制显著影响CD4+ t细胞亚群的生物学，并进一步参与炎症性疾病。CD8+ T细胞与肿瘤细胞之间的串扰在肿瘤微环境中诱导铁下垂。谷胱甘肽过氧化物酶4缺失促进调节性t细胞铁下垂以增强抗肿瘤免疫。

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来源期刊

Clinical and Translational Medicine Multiple-

CiteScore

15.90

自引率

1.90%

发文量

450

审稿时长

4 weeks

期刊介绍： Clinical and Translational Medicine (CTM) is an international, peer-reviewed, open-access journal dedicated to accelerating the translation of preclinical research into clinical applications and fostering communication between basic and clinical scientists. It highlights the clinical potential and application of various fields including biotechnologies, biomaterials, bioengineering, biomarkers, molecular medicine, omics science, bioinformatics, immunology, molecular imaging, drug discovery, regulation, and health policy. With a focus on the bench-to-bedside approach, CTM prioritizes studies and clinical observations that generate hypotheses relevant to patients and diseases, guiding investigations in cellular and molecular medicine. The journal encourages submissions from clinicians, researchers, policymakers, and industry professionals.