Wang-Yang Du, Hui-Fang Wang, Ruo-Nan Sun, Yang Jin, Hai-Feng Wang, Chao Ma, Xu-Wen Li
{"title":"Phomaligol J, a New Cyclohexenone With Antibacterial Activity From a Pufferfish-Associated Fungus Aspergillus austwickii","authors":"Wang-Yang Du, Hui-Fang Wang, Ruo-Nan Sun, Yang Jin, Hai-Feng Wang, Chao Ma, Xu-Wen Li","doi":"10.1002/cbdv.202500503","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>A new cyclohexenone, phomaligol J (<b>1</b>), along with nine known compounds (<b>2–10</b>) were isolated from the liquid culture of the pufferfish-associated <i>Aspergillus austwickii</i> collected from Yangma Island, Yantai. Their structures were determined by extensive spectroscopic data analysis, high resolution electrospray ionization mass spectrometry (HRESIMS), electronic circular dichroism (ECD), and the comparison with reported data in the literature. In bioactivity, all isolated compounds were evaluated for antibacterial activity against 12 bacterial strains. Notably, compound <b>1</b> exhibited moderate antibacterial activity against <i>Staphylococcus aureus</i> with a minimum inhibitory concentration (MIC) value of 40 µg/mL.</p>\n </div>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"22 7","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry & Biodiversity","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202500503","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A new cyclohexenone, phomaligol J (1), along with nine known compounds (2–10) were isolated from the liquid culture of the pufferfish-associated Aspergillus austwickii collected from Yangma Island, Yantai. Their structures were determined by extensive spectroscopic data analysis, high resolution electrospray ionization mass spectrometry (HRESIMS), electronic circular dichroism (ECD), and the comparison with reported data in the literature. In bioactivity, all isolated compounds were evaluated for antibacterial activity against 12 bacterial strains. Notably, compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus with a minimum inhibitory concentration (MIC) value of 40 µg/mL.
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
