Phomaligol J, A New Cyclohexenone with Antibacterial Activity from a Pufferfish Associated Fungus Aspergillus austwickii.

IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemistry & Biodiversity Pub Date : 2025-03-05 DOI:10.1002/cbdv.202500503
Wang-Yang Du, Hui-Fang Wang, Ruo-Nan Sun, Yang Jin, Hai-Feng Wang, Chao Ma, Xu-Wen Li
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引用次数: 0

Abstract

A new cyclohexenone, phomaligol J (1), along with 9 known compounds (2-10) was isolated from the liquid culture of the pufferfish associated Aspergillus austwickii collected from Yangma Island, Yantai. Their structures were determined by extensive spectroscopic data analysis, HRESIMS, electronic circular dichroism (ECD) and the comparison with reported data in the literature. In bioactivity, all isolated compounds were evaluated for antibacterial activity against 12 bacterial strains. Notably, compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) value of 40 µg/mL.

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来源期刊
Chemistry & Biodiversity
Chemistry & Biodiversity 环境科学-化学综合
CiteScore
3.40
自引率
10.30%
发文量
475
审稿时长
2.6 months
期刊介绍: Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.
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