Role of skin-homing t-cells in recurrent episodes of atopic dermatitis: a review.

IF 5.9 2区 医学 Q1 IMMUNOLOGY Frontiers in Immunology Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI:10.3389/fimmu.2025.1489277
Huimin Guo, Huimin Yuan, Yanru Yu, Jingwei Sun, Yan Sun, Yang Tang, Fengjie Zheng
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Abstract

Atopic dermatitis (AD) is a chronic relapsing disease with complex pathogenesis. Among them, inflammation is one of the primary pathogenesis of AD. AD is characterized by infiltration of lymphocytes into the skin's dermis, and the skin homing of lymphocytes plays an essential role in the recurrence of AD. Currently, there is more and more evidence to support this view. This article reviews the relevant role of T lymphocyte skin-homing-related molecules in the recurrence of AD to provide a reference for the cure of AD.

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皮肤归巢t细胞在特应性皮炎复发中的作用:综述。
特应性皮炎(AD)是一种慢性复发性疾病,发病机制复杂。其中,炎症是AD的主要发病机制之一。AD的特点是淋巴细胞浸润到皮肤真皮层,淋巴细胞的皮肤归巢在AD的复发中起着至关重要的作用。目前,有越来越多的证据支持这一观点。本文就T淋巴细胞皮肤归巢相关分子在AD复发中的相关作用进行综述,为AD的治疗提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.80
自引率
11.00%
发文量
7153
审稿时长
14 weeks
期刊介绍: Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.
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