{"title":"Stripe out for brain evolution: Astrocytes go human","authors":"Lara López-González, Víctor Borrell","doi":"10.1016/j.stem.2025.02.008","DOIUrl":null,"url":null,"abstract":"Evolution of the human brain involved neuron and glial cell changes. In this issue of <em>Cell Stem Cell</em>, Ciuba et al.<span><span><sup>1</sup></span></span> identify an epigenetic mechanism central in the evolution of human astrocytes, where small enhancer modifications increased transcription factor binding, orchestrating transcriptomic changes that influence astrocyte structure and function.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"86 1","pages":""},"PeriodicalIF":19.8000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell stem cell","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.stem.2025.02.008","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}
引用次数: 0
Abstract
Evolution of the human brain involved neuron and glial cell changes. In this issue of Cell Stem Cell, Ciuba et al.1 identify an epigenetic mechanism central in the evolution of human astrocytes, where small enhancer modifications increased transcription factor binding, orchestrating transcriptomic changes that influence astrocyte structure and function.
期刊介绍：
Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.
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