{"title":"Photocatalytic α-C(sp3)–H Arylation/Heteroarylation of Amines Enabled by Pyrylium Salt","authors":"Jiemin Ma, Yuhua Zhong, Hu Cai, Wentao Xu","doi":"10.1021/acs.joc.5c00090","DOIUrl":null,"url":null,"abstract":"A general photocatalytic α-C(sp<sup>3</sup>)–H arylation/heteroarylation of amines has been developed. In the presence of the newly designed DPA-TPT, the reaction can operate under mild conditions and produce a diverse array of tertiary benzylic amines in good yields. Additionally, the late-stage arylation of tetracaine demonstrated the practical application of this protocol, highlighting its versatility and efficiency in functionalizing complex molecules.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"12 1","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organic Chemistry","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1021/acs.joc.5c00090","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A general photocatalytic α-C(sp3)–H arylation/heteroarylation of amines has been developed. In the presence of the newly designed DPA-TPT, the reaction can operate under mild conditions and produce a diverse array of tertiary benzylic amines in good yields. Additionally, the late-stage arylation of tetracaine demonstrated the practical application of this protocol, highlighting its versatility and efficiency in functionalizing complex molecules.
期刊介绍：
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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