Colloidal Copper Nanoparticles Loaded with Vanillic Acid as Liquid Dressings: Development, Characterisation and Evaluation

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY Journal of Pharmaceutical Innovation Pub Date : 2025-03-06 DOI:10.1007/s12247-025-09948-9

Mohini Yadav, Neelam Datt, Priyanka Maurya, Vishwambhar Mishra, Shailendra K. Saraf

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Abstract

Purpose

The study aimed to develop liquid dressings containing copper nanoparticles infused with vanillic acid to enhance their antibacterial properties.

Method

PEG 6000 served as a stabilising agent in the chemical reduction process. The Box-Behnken design was employed to optimise the synthesised nanoparticles. Vanillic acid, obtained from Vanilla planifolia, possesses medicinal qualities, promoting wound healing and antioxidant properties. The nanoparticles were integrated into an optimised batch of in-situ film (liquid dressing) and assessed using DSC, FESEM, cytotoxicity analysis, and in-vivo testing.

Result

The optimised batch exhibited an entrapment effectiveness of 90.9%, an in-vitro drug release of 89.6%, a particle size of 97.9 nm, a zeta potential of -31 mV, and a polydispersity index of 0.316.

Conclusion

The liquid dressing exhibited superior wound healing capabilities compared to the pure Vanillic acid solution.

Graphical Abstract

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载香草酸的胶体铜纳米颗粒作为液体敷料：开发、表征和评价

目的研制含铜纳米颗粒注入香草酸的液体敷料，以提高其抗菌性能。方法在化学还原过程中，peg6000作为稳定剂。采用Box-Behnken设计来优化合成的纳米颗粒。香草酸，提取自香草planifolia，具有药用价值，促进伤口愈合和抗氧化性能。将纳米颗粒整合到优化的原位膜（液体敷料）中，并使用DSC， FESEM，细胞毒性分析和体内测试进行评估。结果优化后的样品包封率为90.9%，体外释药率为89.6%，粒径为97.9 nm， zeta电位为-31 mV，多分散指数为0.316。结论与纯香草酸溶液相比，该液体敷料具有更好的创面愈合能力。图形抽象

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来源期刊

Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-

CiteScore

3.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.