{"title":"DNA/RNA Origami Based on Different Scaffolds and Their Biomedical Applications.","authors":"Jing Fan, Changping Yang, Hanyin Zhu, Hong Wang, Xintong Li, Jianbing Liu, Baoquan Ding","doi":"10.1021/acsbiomaterials.5c00154","DOIUrl":null,"url":null,"abstract":"<p><p>Nucleic acids, including DNA and RNA, have been used extensively as building blocks to construct sophisticated nanostructures through complementary base pairing with predetermined shapes and sizes. With remarkable biocompatibility, spatial addressability, and structural programmability, self-assembled nucleic acid biomaterials have found widespread applications in various biomedical researches, including drug delivery, bioimaging, or disease diagnosis. Notably, as one of the representative nanostructures, DNA origami has drawn much attention. In this review, we summarize the latest developments in DNA/RNA origami design based on single-stranded DNA (ssDNA), double-stranded DNA (dsDNA), and single-stranded RNA (ssRNA) scaffolds for a range of biomedical applications, including drug delivery, gene regulation, immunomodulation, and receptor recognition. Additionally, the challenges and future opportunities of DNA/RNA origami in biomedical applications will be discussed.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"2080-2095"},"PeriodicalIF":5.5000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Biomaterials Science & Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1021/acsbiomaterials.5c00154","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Nucleic acids, including DNA and RNA, have been used extensively as building blocks to construct sophisticated nanostructures through complementary base pairing with predetermined shapes and sizes. With remarkable biocompatibility, spatial addressability, and structural programmability, self-assembled nucleic acid biomaterials have found widespread applications in various biomedical researches, including drug delivery, bioimaging, or disease diagnosis. Notably, as one of the representative nanostructures, DNA origami has drawn much attention. In this review, we summarize the latest developments in DNA/RNA origami design based on single-stranded DNA (ssDNA), double-stranded DNA (dsDNA), and single-stranded RNA (ssRNA) scaffolds for a range of biomedical applications, including drug delivery, gene regulation, immunomodulation, and receptor recognition. Additionally, the challenges and future opportunities of DNA/RNA origami in biomedical applications will be discussed.
期刊介绍：
ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics:
Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology
Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions
Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis
Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering
Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends
Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring
Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration
Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials
Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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