Eosinophilic esophagitis manifesting as intractable hiccups in an elderly patient: a case report.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Journal of Medical Case Reports Pub Date : 2025-03-06 DOI:10.1186/s13256-025-05044-1

Sarah Jalloul, Johny Salem, Karam Karam, Clara Chamoun, Louis Chaptini

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Abstract

Background: Eosinophilic esophagitis is a condition characterized clinically by symptoms related to esophageal dysfunction and histologically by a marked eosinophilic infiltrate in the esophageal mucosa. The most typical symptoms of eosinophilic esophagitis include intermittent dysphagia with episodic food impaction and heartburn with propensity for young individuals. The relationship between hiccups and eosinophilic esophagitis is unclear but has been described.

Case report: We report a case of a 93-year-old Middle Eastern male presenting for longstanding treatment-refractory hiccups. Imaging with computed tomography of the chest and abdomen was unremarkable. An upper endoscopy was normal without any endoscopic finding to suggest eosinophilic esophagitis. Given his elevated peripheral eosinophil count, biopsies were taken from mid- and distal esophagus and revealed eosinophilic infiltration in the range of 15 eosinophils per high-power field, favoring a diagnosis of eosinophilic esophagitis. The hiccups resolved following the initiation of eosinophilic esophagitis treatment.

Conclusion: This case underscores the need to consider the diagnosis of eosinophilic esophagitis in the setting of chronic refractory hiccups.

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嗜酸性粒细胞性食管炎表现为顽固性呃嗝1例。

背景：嗜酸性粒细胞性食管炎是一种以食管功能障碍相关症状为临床特征的疾病，组织学上表现为食管黏膜明显的嗜酸性粒细胞浸润。嗜酸性粒细胞性食管炎最典型的症状包括间歇性吞咽困难伴偶发性食物嵌塞和胃灼热，多见于年轻人。打嗝与嗜酸性粒细胞性食管炎之间的关系尚不清楚，但已有报道。病例报告：我们报告一个病例93岁的中东男性提出长期治疗难治性打嗝。胸部和腹部的计算机断层扫描无明显变化。上镜检查正常，未发现嗜酸性食管炎。考虑到患者外周血嗜酸性粒细胞计数升高，从食管中端和远端进行活检，发现每高倍视场有15个嗜酸性粒细胞浸润，有利于诊断嗜酸性粒细胞性食管炎。打嗝在嗜酸性粒细胞性食管炎治疗开始后消失。结论：本病例强调了在慢性难治性呃呃病中考虑嗜酸性粒细胞性食管炎诊断的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Case Reports Medicine-Medicine (all)

CiteScore

1.50

自引率

0.00%

发文量

436

期刊介绍： JMCR is an open access, peer-reviewed online journal that will consider any original case report that expands the field of general medical knowledge. Reports should show one of the following: 1. Unreported or unusual side effects or adverse interactions involving medications 2. Unexpected or unusual presentations of a disease 3. New associations or variations in disease processes 4. Presentations, diagnoses and/or management of new and emerging diseases 5. An unexpected association between diseases or symptoms 6. An unexpected event in the course of observing or treating a patient 7. Findings that shed new light on the possible pathogenesis of a disease or an adverse effect