Elevated levels of C-reactive protein and pig major acute phase protein in lame gestating sows.

IF 2.9 2区农林科学 Q1 VETERINARY SCIENCES Frontiers in Veterinary Science Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI:10.3389/fvets.2025.1505132

Nadia Jakobsen, Inge Larsen, Nicolai R Weber, Peter M H Heegaard, Ken S Pedersen

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Abstract

Introduction: Lameness is a common clinical issue in gestating sows and a leading cause for early culling and antibiotic treatment. Diagnostic tools are limited, but acute acute phase proteins (APPs) could offer a fast and minimally invasive method for optimizing treatment. The aim of this study was to investigate whether APP level measurements can be used as a diagnostic tool, and to identify which major acute phase proteins are elevated in lame gestating sows.

Methods: To determine this, blood samples were collected from the jugular vein of 50 lame and 50 clinically healthy gestating sows from 12 conventional herds. The samples were analyzed for C-reactive protein (CRP), haptoglobin, serum amyloid A, and pig major acute phase protein (Pig-MAP) levels using sandwich ELISA.

Results: C-reactive protein and Pig-MAP were found to be significantly elevated in lame sows compared to clinically healthy sows (p < 0.05). The acute phase protein levels were 22.4 μg/ mL for CRP and 1.19 mg/mL for Pig-MAP in lame sows, compared to 14.7 μg/mL for CRP and 1.06 mg/mL for Pig-MAP in healthy sows.Acute phase protein levels were not associated with clinical signs of inflammation on the affected leg(s), and no differences were seen in hematology parameters between lame and healthy gestating sows.

Conclusion: In this study, lameness was associated with an elevation in C-reactive protein and pig major acute phase protein.

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妊娠跛足母猪c反应蛋白和猪主急性期蛋白水平升高。

简介：跛行是妊娠母猪常见的临床问题，也是早期扑杀和抗生素治疗的主要原因。诊断工具是有限的，但急性急性期蛋白（APPs）可以提供一种快速和微创的方法来优化治疗。本研究的目的是研究APP水平测量是否可以作为一种诊断工具，并确定哪些主要的急性期蛋白在跛妊娠母猪中升高。方法：对12个常规母猪群中50头瘸腿母猪和50头临床健康妊娠母猪进行颈静脉采血。采用夹心ELISA法分析样品的c反应蛋白（CRP）、接触珠蛋白（haptoglobin）、血清淀粉样蛋白A和猪急性期蛋白（pig - map）水平。结果：与临床健康母猪相比，瘸腿母猪的c反应蛋白和pig - map显著升高（p ）。结论：本研究中，瘸腿与猪的c反应蛋白和猪急性期蛋白升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Veterinary Science Veterinary-General Veterinary

CiteScore

4.80

自引率

9.40%

发文量

1870

审稿时长

14 weeks

期刊介绍： Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.