{"title":"The impact of allergic contact dermatitis on the inflammatory response and repair in wound healing process.","authors":"Wei Zhang, Jiabao Xu, Songyan Qu, Hui Peng","doi":"10.3389/fmed.2025.1524198","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Skin trauma and the subsequent wound healing process present significant challenges for healthcare systems and patients globally. Allergic contact dermatitis (ACD) was a delayed-type hypersensitivity reaction that can disrupt the normal wound repair process due to prolonged inflammation and immune dysregulation. However, the specific impact of ACD on the inflammatory response and repair in wound healing remains incompletely understood. This study aimed to investigate the influence of ACD on the inflammatory response and repair during the wound healing process.</p><p><strong>Methods: </strong>This study was a retrospective cohort study. A total of 120 patients with skin trauma treated at Henan Provincial People's Hospital from January 2023 to December 2023 were included. There were 69 cases of control and 51 cases of ACD. Inclusion and exclusion criteria were defined, and various indicators, including patient data, inflammatory factors, cell detection, and wound healing assessment, were measured and analyzed using appropriate statistical methods.</p><p><strong>Results: </strong>The study revealed significant differences between the control and ACD groups. ACD was associated with higher levels of TNF-<i>α</i>, IL-6, IL-1β, C-reactive protein, and IL-8 compared to control (<i>p</i> < 0.05). Additionally, ACD group exhibited increased counts of macrophages, neutrophils, T lymphocytes, B lymphocytes, and mast cells compared to the control group (<i>p</i> < 0.05). Moreover, ACD was linked to delayed wound closure time and differences in the distribution of healing degrees (<i>p</i> < 0.05). Correlation analysis indicated significant associations among ACD, inflammatory markers, cellular responses, wound closure time, and healing degree (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The study demonstrates that ACD exerts a substantial impact on the inflammatory response, cellular components, and wound healing parameters in the context of skin trauma. The heightened levels of inflammatory markers, altered cellular responses, and delayed wound closure observed in ACD patients underscore the need for targeted interventions tailored to optimize wound repair in this population.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1524198"},"PeriodicalIF":3.1000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879791/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fmed.2025.1524198","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
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Abstract
Background: Skin trauma and the subsequent wound healing process present significant challenges for healthcare systems and patients globally. Allergic contact dermatitis (ACD) was a delayed-type hypersensitivity reaction that can disrupt the normal wound repair process due to prolonged inflammation and immune dysregulation. However, the specific impact of ACD on the inflammatory response and repair in wound healing remains incompletely understood. This study aimed to investigate the influence of ACD on the inflammatory response and repair during the wound healing process.
Methods: This study was a retrospective cohort study. A total of 120 patients with skin trauma treated at Henan Provincial People's Hospital from January 2023 to December 2023 were included. There were 69 cases of control and 51 cases of ACD. Inclusion and exclusion criteria were defined, and various indicators, including patient data, inflammatory factors, cell detection, and wound healing assessment, were measured and analyzed using appropriate statistical methods.
Results: The study revealed significant differences between the control and ACD groups. ACD was associated with higher levels of TNF-α, IL-6, IL-1β, C-reactive protein, and IL-8 compared to control (p < 0.05). Additionally, ACD group exhibited increased counts of macrophages, neutrophils, T lymphocytes, B lymphocytes, and mast cells compared to the control group (p < 0.05). Moreover, ACD was linked to delayed wound closure time and differences in the distribution of healing degrees (p < 0.05). Correlation analysis indicated significant associations among ACD, inflammatory markers, cellular responses, wound closure time, and healing degree (p < 0.05).
Conclusion: The study demonstrates that ACD exerts a substantial impact on the inflammatory response, cellular components, and wound healing parameters in the context of skin trauma. The heightened levels of inflammatory markers, altered cellular responses, and delayed wound closure observed in ACD patients underscore the need for targeted interventions tailored to optimize wound repair in this population.
背景：皮肤创伤和随后的伤口愈合过程对全球医疗保健系统和患者提出了重大挑战。过敏性接触性皮炎（ACD）是一种延迟型超敏反应，可因长期炎症和免疫失调而破坏正常的伤口修复过程。然而，ACD对炎症反应和伤口愈合修复的具体影响尚不完全清楚。本研究旨在探讨ACD对创面愈合过程中炎症反应及修复的影响。方法：本研究为回顾性队列研究。共纳入2023年1月至2023年12月在河南省人民医院治疗的120例皮肤外伤患者。对照组69例，ACD 51例。定义纳入和排除标准，并使用适当的统计方法测量和分析各种指标，包括患者资料、炎症因子、细胞检测和伤口愈合评估。结果：研究显示对照组与ACD组之间存在显著差异。与对照组相比，ACD与更高水平的TNF-α、IL-6、IL-1β、c反应蛋白和IL-8相关（p p p p ）。结论：研究表明，ACD对皮肤创伤背景下的炎症反应、细胞成分和伤口愈合参数具有实质性影响。在ACD患者中观察到的炎症标志物水平升高、细胞反应改变和伤口愈合延迟，强调了针对这一人群进行针对性干预以优化伤口修复的必要性。
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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