F-wave motor unit numbers do not change in diabetic polyneuropathy: does it indicate a pathophysiologic mechanism for generating F-waves?

IF 1.7 4区 医学 Q3 CLINICAL NEUROLOGY Neurological Research Pub Date : 2025-03-05 DOI:10.1080/01616412.2025.2472828
Isil Yazıcı Gencdal, Nermin Gorkem Sirin, Tugrul Artug, Irem Ilgezdi, Ummu Mutlu, Elif Kocasoy-Orhan, Mehmet Baris Baslo, Nevin Dinccag, Ali Emre Oge
{"title":"F-wave motor unit numbers do not change in diabetic polyneuropathy: does it indicate a pathophysiologic mechanism for generating F-waves?","authors":"Isil Yazıcı Gencdal, Nermin Gorkem Sirin, Tugrul Artug, Irem Ilgezdi, Ummu Mutlu, Elif Kocasoy-Orhan, Mehmet Baris Baslo, Nevin Dinccag, Ali Emre Oge","doi":"10.1080/01616412.2025.2472828","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Motor unit number estimation (MUNE) methods including the one using F-waves (F-MUNE) are used to detect axonal loss in polyneuropathies. The aim of this study is to evaluate the amount of axonal loss by repeater F-wave parameters and F-MUNE in patients with type 2 diabetes mellitus (DM).</p><p><strong>Methods: </strong>In 24 controls and 49 patients with diabetic polyneuropathy, 90 F-waves elicited with supramaximal and 300 F-waves with submaximal stimulation of the ulnar nerve were recorded from the abductor digiti minimi muscle. F-MUNE values were calculated using the automated software with the repeater F-waves elicited using submaximal stimulation.</p><p><strong>Results: </strong>Ulnar repeater F-wave index and repeater neuron index were found to be significantly higher in patients with DM compared with the control group. The amplitudes of F-waves elicited using both sub- and supramaximal stimulus intensities were reduced in patients with polyneuropathy when compared with controls. The F-MUNE values were found to be similar between the two groups.</p><p><strong>Discussion: </strong>Repeater F-wave parameters recorded from the upper extremity might indicate the presence of axon loss in DM-related polyneuropathy. However, F-MUNE failed to reveal axonal loss in diabetic polyneuropathy probably because of its length-dependent nature and the dominance of low-amplitude F-waves, which might be secondary to several yet unknown mechanisms, mainly related to sensory fiber dysfunction.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/01616412.2025.2472828","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives: Motor unit number estimation (MUNE) methods including the one using F-waves (F-MUNE) are used to detect axonal loss in polyneuropathies. The aim of this study is to evaluate the amount of axonal loss by repeater F-wave parameters and F-MUNE in patients with type 2 diabetes mellitus (DM).

Methods: In 24 controls and 49 patients with diabetic polyneuropathy, 90 F-waves elicited with supramaximal and 300 F-waves with submaximal stimulation of the ulnar nerve were recorded from the abductor digiti minimi muscle. F-MUNE values were calculated using the automated software with the repeater F-waves elicited using submaximal stimulation.

Results: Ulnar repeater F-wave index and repeater neuron index were found to be significantly higher in patients with DM compared with the control group. The amplitudes of F-waves elicited using both sub- and supramaximal stimulus intensities were reduced in patients with polyneuropathy when compared with controls. The F-MUNE values were found to be similar between the two groups.

Discussion: Repeater F-wave parameters recorded from the upper extremity might indicate the presence of axon loss in DM-related polyneuropathy. However, F-MUNE failed to reveal axonal loss in diabetic polyneuropathy probably because of its length-dependent nature and the dominance of low-amplitude F-waves, which might be secondary to several yet unknown mechanisms, mainly related to sensory fiber dysfunction.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Neurological Research
Neurological Research 医学-临床神经学
CiteScore
3.60
自引率
0.00%
发文量
116
审稿时长
5.3 months
期刊介绍: Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.
期刊最新文献
Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis. Can lactate levels predict progression to status epilepticus in generalized convulsive epileptic seizures? Effectiveness of acupoint injection combined with specific electromagnetic spectrum irradiation and acupuncture on peripheral facial paralysis. F-wave motor unit numbers do not change in diabetic polyneuropathy: does it indicate a pathophysiologic mechanism for generating F-waves? Genetic association study between rs2234253 (p.T96K) variant of TREM2 and Alzheimer's disease in a Tunisian population.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1