{"title":"The Potential Risk of Povidone-Iodine in Sperm Quality: A Case Report.","authors":"Fei Shi, Ling Wang, Changying Xing, Yannan Yang, Yubing Liu, Yunjing Xue, Sanwei Guo, Ri-Cheng Chian","doi":"10.36849/JDD.7342","DOIUrl":null,"url":null,"abstract":"<p><p>To report a rare case of severe oligoasthenoteratozoospermia which seems to be associated with long-term topical povidone-iodine (PVP-I) therapy. A 45-year-old man with secondary infertility was diagnosed with mild asthenospermia before undergoing in vitro fertilization (IVF). A repeat sperm analysis (SA) on June 30, 2022, after three months of using compound PVP-I liniment to treat fungal infection under a fingernail and toenail, revealed severe oligoasthenoteratozoospermia. After 77 days of drug withdrawal, sperm concentration, and normal morphology gradually returned to normal, but motility was only partially restored. It seems that the usage of PVP-I has a side effect of causing a decline in sperm quality. Although the exact mechanism of this adverse effect of PVP-I is unclear, men who are in fertility treatment should be informed of the potential risks. J Drugs Dermatol. 2025;24(3):e11-e13. doi:10.36849/JDD.7342.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"24 3","pages":"e11-e13"},"PeriodicalIF":1.8000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drugs in Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.36849/JDD.7342","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
To report a rare case of severe oligoasthenoteratozoospermia which seems to be associated with long-term topical povidone-iodine (PVP-I) therapy. A 45-year-old man with secondary infertility was diagnosed with mild asthenospermia before undergoing in vitro fertilization (IVF). A repeat sperm analysis (SA) on June 30, 2022, after three months of using compound PVP-I liniment to treat fungal infection under a fingernail and toenail, revealed severe oligoasthenoteratozoospermia. After 77 days of drug withdrawal, sperm concentration, and normal morphology gradually returned to normal, but motility was only partially restored. It seems that the usage of PVP-I has a side effect of causing a decline in sperm quality. Although the exact mechanism of this adverse effect of PVP-I is unclear, men who are in fertility treatment should be informed of the potential risks. J Drugs Dermatol. 2025;24(3):e11-e13. doi:10.36849/JDD.7342.
期刊介绍：
The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology.
We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality.
Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.
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