Macrophage-derived lncRNAs in cancer: regulators of tumor progression and therapeutic targets.

IF 3.5 4区医学 Q2 ONCOLOGY Medical Oncology Pub Date : 2025-03-06 DOI:10.1007/s12032-025-02643-2

Muath Suliman, Raed Obaid Saleh, Muktesh Chandra, Khetam Habeeb Rasool, Majid Jabir, Sabrean F Jawad, Thikra F Hasan, Mithilesh Singh, Manmeet Singh, Abhayveer Singh

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Abstract

Macrophages are key tumor microenvironment (TME) regulators, exhibiting remarkable plasticity that enables them to either suppress or promote cancer progression. Emerging evidence highlights the critical role of macrophage-derived long non-coding RNAs (lncRNAs) in shaping tumor immunity, influencing macrophage polarization, immune evasion, angiogenesis, metastasis, and therapy resistance. This review comprehensively elucidates the functional roles of M1- and M2-associated lncRNAs, detailing their molecular mechanisms and impact on cancer pathogenesis. In summary, elucidating the roles of lncRNAs derived from macrophages in cancer progression offers new avenues for therapeutic strategies, significantly improving patient outcomes in the fight against the disease. Further research into the functional significance of these lncRNAs and the development of targeted therapies is essential to harness their potential fully in clinical applications. We further explore their potential as biomarkers for cancer prognosis and therapeutic targets for modulating macrophage activity to enhance anti-cancer immunity. Targeting macrophage-derived lncRNAs represents a promising avenue for precision oncology, offering novel strategies to reshape the TME and improve cancer treatment outcomes.

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巨噬细胞来源的lncrna在癌症中的作用：肿瘤进展的调节因子和治疗靶点。

巨噬细胞是关键的肿瘤微环境（TME）调节剂，表现出显著的可塑性，使它们能够抑制或促进癌症的进展。新出现的证据强调了巨噬细胞来源的长链非编码rna （lncRNAs）在塑造肿瘤免疫、影响巨噬细胞极化、免疫逃避、血管生成、转移和治疗抵抗方面的关键作用。本文全面阐述了M1-和m2相关lncrna的功能作用，详细介绍了它们的分子机制和对癌症发病的影响。总之，阐明巨噬细胞衍生的lncrna在癌症进展中的作用为治疗策略提供了新的途径，显著改善了患者与疾病作斗争的结果。进一步研究这些lncrna的功能意义和开发靶向治疗对于充分利用它们在临床应用中的潜力至关重要。我们进一步探索它们作为癌症预后的生物标志物和调节巨噬细胞活性以增强抗癌免疫的治疗靶点的潜力。靶向巨噬细胞来源的lncRNAs代表了精确肿瘤学的一个有前途的途径，提供了重塑TME和改善癌症治疗结果的新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Oncology 医学-肿瘤学

CiteScore

4.20

自引率

2.90%

发文量

259

审稿时长

1.4 months

期刊介绍： Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.