Dermabond Prineo: a systematic review and meta-analysis.

IF 1.5 4区医学 Q3 DERMATOLOGY Journal of wound care Pub Date : 2025-03-02 DOI:10.12968/jowc.2023.0024

Shreya Kulkarni, Matthew Goodbun, Mohammed Chowdhury, Philip W Stather

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引用次数: 0

Abstract

Objective: Dermabond Prineo (Ethicon Inc., US) is a combination of a skin adhesive applied over a polyester mesh to reinforce and share tension equally over the surgical wound with the aim of reducing closure time and improving wound healing. The aims of this systematic review were to assess published data on Dermabond Prineo regarding infection rates, delayed wound healing, cosmetic appearance and application time compared to conventional wound closure techniques across multiple surgical procedures.

Method: A literature search was conducted according to PRISMA guidelines. The primary outcome was the incidence of wound infection after Dermabond Prineo compared to controls, namely traditional methods of wound closure such as staples, sutures and adhesives. Secondary outcome measures included allergic reactions and time taken for application.

Results: A literature search using PubMed, SCOPUS and Science Direct identified 52 studies, of which 19 were eligible for qualitative synthesis and 12 for meta-analysis. The studies included reflected a broad range of applications of Dermabond Prineo for wound closure in abdominoplasty, mammoplasty and arthroplasty. Overall, all studies reporting on time taken for application found that Dermabond Prineo reduced time for wound closure. Meta-analysis identified a statistically significant reduction in wound infection rates (Dermabond Prineo 1.51%, control 2.13%; OR: 0.65 (0.46, 0.91); p=0.01) and a reduction in delayed wound healing (Dermabond Prineo 0.99%, control 1.79%; OR: 0.42 (0.18, 0.98); p=0.05). All three studies reporting on outcomes of scar cosmesis or long-term maturation attested to improved cosmetic results compared with sutures. The cost-effectiveness of Dermabond Prineo with a hypothetical model was discussed in two studies which concluded that it could achieve savings of $50-76 USD per patient, while a retrospective model found no statistically significant difference in total hospital costs or operating room time.

Conclusion: In this review, Dermabond Prineo showed lower wound infection rates and a reduction in delayed wound healing. Further studies are required to assess cost-effectiveness in a real-world setting.

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来源期刊

Journal of wound care DERMATOLOGY-

CiteScore

2.90

自引率

10.50%

发文量

215

期刊介绍： Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.