[Research progress on B cells in chronic hepatitis B].

Abstract

B cells play a key role in humoral immunity and participate in the clearance of hepatitis B virus (HBV) through antibody production, antigen presentation, and immune regulation. Variations in immunological responses to different HBV antigens show antigenic heterogeneity in B cells during HBV infection. In recent years, it has been found that hepatitis B surface antibody-specific B cells are abnormally differentiated, while hepatitis B core antibody-specific B cells are relatively intact in patients with chronic hepatitis B (CHB). Additionally, defects in the non-antibody-generating functions of B cell lead to persistent HBV infection. This article provides important insights for understanding the role and function of B cells in chronic HBV infection and a scientific basis for the development of novel therapeutic strategies..