Does dietary intake of vitamin A and beta-carotene increase the risk of hypertension?

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Endocrinology & Metabolism Pub Date : 2024-11-14 eCollection Date: 2024-12-01 DOI:10.1097/XCE.0000000000000316
Sasan Rahmanian, Zahra Salimi, Mohammad Masoumvand, Zohre Aghakhani Nejad, Mohamadtaghi Ghorbani Hesari, Seyed Reza Mirshafaei, Mohammad Keshavarz Mohammadian, Khadijeh Abbasi Mobarakeh, Masoomeh Ataei Kachooei, Ali Shamsi-Goushki, Sara Khoshdooz, Parsa Bahmani, Saeid Doaei, Akram Kooshki, Maryam Gholamalizadeh
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引用次数: 0

Abstract

Background: Hypertension (HTN) is a major global public health issue influenced by genetics and lifestyle factors such as diet and psychological stress. Previous research suggests a potential link between HTN and dietary vitamin A intake. This study aims to explore the association between HTN and the intake of various forms of vitamin A.

Methods: This cross-sectional study was conducted on 1239 patients with HTN and 2945 normotensive individuals aged 35-70 years in Sabzevar, Iran. Dietary vitamin A intake was assessed using the Nutritionist IV software and a food frequency questionnaire.

Result: A positive association was found between HTN with total vitamin A intake [odds ratio (OR): 1.03, 95% confidence interval (CI): 1.01-1.05, P = 0.04] and β-carotene intake (OR: 1.03, 95% CI: 1.02-1.05, P = 0.03) after adjusting for age and sex. These associations remained statistically significant after adjusting for physical activity and BMI. The association between HTN and β-carotene intake remained significant after additional adjustment for calorie intake. No significant association was observed between dietary retinol intake and HTN.

Conclusion: Increased dietary intake of vitamin A and β-carotene may be associated with a higher risk of HTN. Further longitudinal studies are needed to confirm these findings and elucidate the underlying mechanisms.

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来源期刊
Cardiovascular Endocrinology & Metabolism
Cardiovascular Endocrinology & Metabolism CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.60
自引率
0.00%
发文量
24
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