Proceedings of the Alzheimer’s Diagnosis in Older Adults with Chronic Conditions (ADACC) Network Inaugural Annual Conference

Michelle M Mielke, Nicole R Fowler, Heather E Whitson, Heidi D Klepin, Antoine R Trammell, Ambar Kulshreshtha, Kyra S O’Brien, Margaret Manchester, Marcel E Salive, Jeff Williamson
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Abstract

The Alzheimer’s Disease in Older Adults with Chronic Conditions (ADACC) Network is funded by the National Institute on Aging as a U24 cooperative agreement. ADACC is an inclusive, multidisciplinary group across multiple institutions that is charged with the task of developing evidence-based strategies for the use and implementation of Alzheimer’s disease and related dementias (AD/ADRD) biomarkers among older adults with cognitive impairment and multiple chronic conditions (MCCs). This report summarizes highlights of the First Annual Symposium of ADACC, which was held in Winston-Salem, North Carolina, in April 2024. An overview of the ADACC network and goals were initially described, followed by a state of the science integrating biomarkers, AD/ADRD, and multiple chronic conditions. Multiple presentations on a variety of topics were featured, including the significance of MCCs in AD/ADRD, the effects of MCCs on Alzheimer’s blood-based biomarkers, the incorporation of AD/ADRD biomarkers into cancer care, the need to address racial and biomarker disparities, clinician and patient perspectives on plasma AD/ADRD biomarker testing, and ethical considerations. ADACC emphasized the importance of supporting emerging researchers and fostering a collaborative environment.
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患有慢性疾病的老年人阿尔茨海默病(ADACC)网络由美国国家老龄化研究所(National Institute on Aging)作为 U24 合作协议资助。ADACC 是一个跨多个机构的包容性多学科小组,其任务是为在患有认知障碍和多种慢性疾病 (MCC) 的老年人中使用和实施阿尔茨海默病及相关痴呆症 (AD/ADRD) 生物标志物制定循证策略。本报告总结了 2024 年 4 月在北卡罗来纳州温斯顿-塞勒姆举行的 ADACC 第一届年度研讨会的要点。会议首先概述了 ADACC 网络和目标,然后介绍了整合生物标记物、AD/ADRD 和多种慢性疾病的科学现状。会议就各种主题进行了多场演讲,包括MCCs在AD/ADRD中的意义、MCCs对基于阿尔茨海默氏症血液的生物标志物的影响、将AD/ADRD生物标志物纳入癌症治疗、解决种族和生物标志物差异的必要性、临床医生和患者对血浆AD/ADRD生物标志物检测的看法以及伦理方面的考虑。ADACC 强调了支持新兴研究人员和营造合作环境的重要性。
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