T.S. FitzMaurice , C. McCann , R. Bedi , D.S. Nazareth , M.J. Walshaw , P.S. McNamara
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引用次数: 0
Abstract
BACKGROUND
As the lifespan of people with CF (pwCF) improves, sensitive markers of lung health are needed. Dynamic chest radiography (DCR) is a low ionising radiation dose cineradiographic imaging system that provides real-time information on moving thoracic structures. We examined whether DCR provides quantitative motion analysis that correlates with pulmonary function, anthropometric and clinical variables in pwCF, to explore DCR as a marker of lung health.
METHODS
In this prospective, observational, single-centre, non-controlled study, participantsunderwent DCR and spirometry. We measured DCR parameters such as diaphragm motion and change in projected lung area (ΔPLA). The study is registered on the ________ registry (ID __________). Correlation was assessed using Spearman’s coefficient, and relationships between DCR and spirometric variables using linear regression modelling. Descriptive statistics are reported as mean ± standard deviation and median (interquartile range) as appropriate.
RESULTS
We assessed 129 adult pwCF (age 29[12] years, 48 female, ppFEV1 69±25). Average inspiratory lung area (PLAinsp) was 424±72cm2, and expiratory lung area (PLAexp) 325±68cm2. Left diaphragm motion range was 34±12mm, right 29±12mm. ΔPLA correlated with FEV1 (ρ=0.70,P<0.001). PLAinsp correlated with FVC (ρ=0.56,P<0.001). PLAexp correlated with FEV1/FVC ratio (ρ=-0.49,P<0.001). BMI correlated with ΔPLA (ρ=0.29,P=0.001) and deep breathing hemidiaphragm excursion (right, ρ=0.4,P<0.001; left 0.39,P<0.001).
CONCLUSIONS
This study is the first to describe diaphragm motion and projected lung areas using DCR in non-exacerbating adult pwCF, and complements work by our group demonstrating change in DCR parameters in pwCF undergoing pharmacological interventions. DCR shows potential as a tool to investigate lung health in pwCF.
期刊介绍:
Clinical Radiology is published by Elsevier on behalf of The Royal College of Radiologists. Clinical Radiology is an International Journal bringing you original research, editorials and review articles on all aspects of diagnostic imaging, including:
• Computed tomography
• Magnetic resonance imaging
• Ultrasonography
• Digital radiology
• Interventional radiology
• Radiography
• Nuclear medicine
Papers on radiological protection, quality assurance, audit in radiology and matters relating to radiological training and education are also included. In addition, each issue contains correspondence, book reviews and notices of forthcoming events.