A comprehensive review of fused imidazonaphthyridine derivatives: Synthetic approaches and biological applications

IF 3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Bioorganic & Medicinal Chemistry Pub Date : 2025-02-28 DOI:10.1016/j.bmc.2025.118141

Siew Fang Wong, Joo Kheng Goh

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Abstract

Fused heterocyclic imidazonaphthyridine compounds stand at the forefront of global research, captivating remarkable interest in medicinal and synthetic organic chemistry. These compounds possess a range of potent biological and pharmacological properties, rendering them invaluable for medical and therapeutic research, particularly in drug design and discovery. Despite their significance, no dedicated review has focused on fused heterocyclic imidazonaphthyridine derivatives. This comprehensive review aims to consolidate and explore the cutting-edge synthesis approaches tailored specifically for these unique imidazonaphthyridine derivatives. It highlights their current applications in various biological realms and provides insights into potential future trajectories. By steering forthcoming research endeavours towards innovative design and synthesis of novel imidazonaphthyridines, this review seeks to diversify these compounds, paving the way for biological applications that have yet to be fully realized. Overall, as a burgeoning area of research, this review underscores the potential of imidazonaphthyridines as promising candidates for biomedical applications, offering a snapshot of current research and suggesting future avenues for investigation.

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融合咪唑萘啶衍生物的综合综述：合成方法和生物学应用

融合杂环咪唑萘啶化合物站在全球研究的前沿，在药物和合成有机化学中引起了极大的兴趣。这些化合物具有一系列强有力的生物学和药理学特性，使它们对医学和治疗研究，特别是在药物设计和发现方面具有不可估量的价值。尽管它们具有重要意义，但没有专门的综述集中在融合杂环咪唑萘啶衍生物上。这篇综合综述旨在巩固和探索专门为这些独特的咪唑萘啶衍生物量身定制的尖端合成方法。它突出了它们在各种生物领域的当前应用，并提供了对潜在未来轨迹的见解。通过指导即将开展的研究工作，以创新的设计和合成新的咪唑萘啶，本综述旨在使这些化合物多样化，为尚未完全实现的生物应用铺平道路。总的来说，作为一个新兴的研究领域，本综述强调了咪唑萘啶作为生物医学应用的有希望的候选物的潜力，提供了当前研究的快照，并提出了未来的研究途径。

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来源期刊

Bioorganic & Medicinal Chemistry 医学-生化与分子生物学

CiteScore

6.80

自引率

2.90%

发文量

413

审稿时长

17 days

期刊介绍： Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.