Performance evaluation of green and conventional solvents in reversed-phase liquid chromatography based on the separation of non-polar and polar substances

IF 9.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Green Chemistry Pub Date : 2025-01-14 DOI:10.1039/d4gc05737f

Oktawia Kalisz , Gabriela Hulicka , Marek Tobiszewski , Szymon Bocian

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Abstract

This study investigated the potential for replacing conventional solvents such as acetonitrile (ACN) and methanol (MeOH) with greener alternatives – ethanol (EtOH) and dimethyl carbonate (DMC) – in chromatographic separations. The aim was to assess whether these environmentally friendly solvents could achieve comparable separation performance while reducing the environmental impact of the analyses. Chromatographic separations were carried out on two different mixtures: non-polar and polar, using three stationary phases with different surface properties (C18, diphenyl and perfluorinated phenyl). The Technique for Order of Preference by Similarity to Ideal Solution algorithm (TOPSIS) was used to select the optimal conditions for ultra-high performance liquid chromatography (UHPLC) separations, integrating multiple criteria, including chromatographic run time, tailing ratios, resolution and solvent-related environmental hazards. The results show that EtOH and DMC can effectively replace traditional solvents without compromising separation performance, confirming that sustainable analytical methods for mixtures of non-polar and polar compounds are achievable with green solvents.

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基于非极性和极性物质分离的反相液相色谱绿色溶剂和常规溶剂的性能评价

本研究探讨了用更环保的替代品-乙醇（EtOH）和碳酸二甲酯(DMC) -在色谱分离中取代传统溶剂（如乙腈（ACN）和甲醇（MeOH））的潜力。目的是评估这些环境友好型溶剂是否能够在减少分析对环境影响的同时达到类似的分离性能。采用三种具有不同表面性质的固定相（C18、二苯基和全氟苯基），对非极性和极性两种不同的混合物进行色谱分离。采用理想溶液相似度优先排序技术（TOPSIS），综合色谱运行时间、尾矿比、分辨率和溶剂相关环境危害等多项指标，优选出超高效液相色谱（UHPLC）分离的最佳条件。结果表明，EtOH和DMC可以在不影响分离性能的情况下有效地取代传统溶剂，证实了绿色溶剂可以实现非极性和极性化合物混合物的可持续分析方法。

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来源期刊

Green Chemistry 化学-化学综合

CiteScore

16.10

自引率

7.10%

发文量

677

审稿时长

1.4 months

期刊介绍： Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.