Recent advances in tailored chitosan-based hydrogels for bone regeneration and repair

Abstract

The increasing prevalence of bone injuries and the current lack of effective repair solutions present a significant clinical challenge. Chitosan-based hydrogels have gained widespread use in bone regeneration and repair due to their favorable biocompatibility, biodegradability, and antimicrobial properties. Advances in preparation techniques have enabled the development of various tailored chitosan-based hydrogels, including nanogels, nanofibers, microspheres, and scaffolds, which are successfully applied in bone tissue regeneration. However, there is currently a lack of comprehensive reviews covering tailored chitosan hydrogels specifically for bone tissue repair. This paper addresses that gap by comprehensively summarizing the preparation processes of tailored chitosan-based hydrogels, along with their specific applications in bone regeneration. It aims to inspire innovative designs for improved chitosan-based hydrogels and foster expanded applications, ultimately leading to better therapeutic outcomes for patients with bone-related diseases.