RETRACTED: Role of lymphadenectomy in advanced ovarian cancer—a subgroup analysis of the patients excluded from the LION trial (the Charité cohort)

IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY International Journal of Gynecological Cancer Pub Date : 2025-02-15 DOI:10.1016/j.ijgc.2025.101683
Robert Armbrust, Christina Fotopoulou, Dario Zocholl, Radoslav Chekerov, Mustafa Zelal Muallem, Iona Braicu, Klaus Pietzner, Philipp Harter, Jalid Sehouli
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Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). This article has been retracted at the request of the Editors. After careful consideration, the Editorial Team has made the decision to retract the manuscript titled “Role of lymphadenectomy in advanced ovarian cancer—a subgroup analysis of the patients excluded from the LION trial (the Charité cohort)’". The decision is based on numerous discrepancies and substantial modifications introduced following the last formal review by the Editorial Team. While the Editors acknowledge that revisions are a natural and expected part of the editorial process, the extent and nature of these changes raised serious concerns regarding the consistency and reliability of the data presented. Maintaining the highest standards of scientific rigor and transparency is central to our journal's mission, and as such, we believe this retraction is necessary.

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淋巴结切除术在晚期卵巢癌中的作用——对LION试验(charit队列)中排除的患者的亚组分析。
目的:LION III期临床试验发现,对于前期细胞减少最佳且淋巴结外观正常的晚期卵巢癌患者,系统性淋巴结切除术没有治疗效果。术中随机选取患者,排除无肿瘤或经检查或触诊有可疑/肿大淋巴结而不能手术的患者。该分析集中于仅因淋巴结肿大而被排除的组的结果。方法:这是一项在慈善大学医院进行的随机对照试验的单中心、回顾性亚组分析。我们评估的患者与LION试验中的相同。排除淋巴结后,无肿瘤的疑似大体积/可疑淋巴结患者行全系统淋巴结切除术。根据与LION试验相同的终点对患者进行分析,并与原始研究进行比较。结果:总体而言,202例患者中位年龄为61岁(范围;37-74);83.6%为III/IV期疾病(n = 122),主要为高级别浆液组织学(72%,n = 145)。术中排除患者的肿瘤完全切除率(45%,n = 55)明显低于纳入患者(92%,n = 112),对总生存率和无进展生存率有显著的负面影响(p = 0.042)。在最初被排除的患者中,只有60% (n = 33)的淋巴结在组织学上呈阳性,尽管38.8% (n = 21)的患者被外科医生认为体积较大。接受最佳手术并被排除在原始LION研究之外的患者与被纳入研究的患者之间的无进展生存期或总生存期没有显著差异,无论其组织学淋巴结状态如何以及是否进行了淋巴结切除术(p = 0.4, 95% CI 24.8至39)。结论:卵巢癌患者在术前无肉眼残留病变的情况下,只要切除任何肿大淋巴结,无论是否有肿大淋巴结,生存率均相同。此外,我们证明外科医生对术中淋巴结的评估是主观的,往往是不准确的。
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来源期刊
CiteScore
6.60
自引率
10.40%
发文量
280
审稿时长
3-6 weeks
期刊介绍: The International Journal of Gynecological Cancer, the official journal of the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology, is the primary educational and informational publication for topics relevant to detection, prevention, diagnosis, and treatment of gynecologic malignancies. IJGC emphasizes a multidisciplinary approach, and includes original research, reviews, and video articles. The audience consists of gynecologists, medical oncologists, radiation oncologists, radiologists, pathologists, and research scientists with a special interest in gynecological oncology.
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