Boosting the antibacterial potency of natural products through nanotechnologies

IF 5.2 2区 医学 Q1 PHARMACOLOGY & PHARMACY International Journal of Pharmaceutics Pub Date : 2025-04-15 Epub Date: 2025-03-07 DOI:10.1016/j.ijpharm.2025.125437
Min Jiao , Weiwen Kong , Wenjuan Liu , Zirong Dong , Jinlong Yang , Zibo Wei , Xinrui Lu , Yuning Wei , Jie Zhuang
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Abstract

The advent of bacterial resistance has led to a notable challenge in effectively treating bacterial infections. This highlights the urgent need for the development of novel and effective drugs to combat bacterial infections. Medicinal plants, with their rich and diverse natural compounds, represent a valuable source for the discovery of novel antibacterial agents. Many of these natural compounds exhibit strong antibacterial functions, offering a promising direction for the development of antibacterial drugs. Furthermore, the application of nanotechnology in the development of antibacterial natural products has become a topic of considerable interest due to the advantages it offers, including the potential to enhance drug solubility. The efficacy of natural antibacterial agents is significantly enhanced through nanotechnology. This review offers a comprehensive overview of recent advances in the delivery of natural antibacterial compounds using a range of nanoformulation strategies.

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通过纳米技术提高天然产物的抗菌效力。
细菌耐药性的出现给有效治疗细菌感染带来了显著的挑战。这凸显了开发新型有效药物来对抗细菌感染的迫切需要。药用植物具有丰富多样的天然化合物,是发现新型抗菌剂的宝贵资源。这些天然化合物中有许多具有较强的抗菌功能,为抗菌药物的开发提供了一个有希望的方向。此外,纳米技术在抗菌天然产物开发中的应用已经成为一个相当感兴趣的话题,因为它提供的优势,包括提高药物溶解度的潜力。纳米技术显著提高了天然抗菌剂的抗菌效果。这篇综述提供了使用一系列纳米制剂策略的天然抗菌化合物的递送的最新进展的全面概述。
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来源期刊
CiteScore
10.70
自引率
8.60%
发文量
951
审稿时长
72 days
期刊介绍: The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.
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