Exploring the antidiabetic effect of various therapeutic essential oils synergistically with repaglinide.

IF 3.7 3区 医学 Q2 CHEMISTRY, MEDICINAL Journal of pharmaceutical sciences Pub Date : 2025-03-07 DOI:10.1016/j.xphs.2025.103721
Omnia M Sarhan, Samaa O Abdelqader, Mostafa S A Mostafa, Manar A E Badawi, Mohamed A M Ahmed, Waleed G A El Sayed, Mostafa I Gebril
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Abstract

Objective: This study aimed to evaluate the antidiabetic efficacy of microemulsions formulated with cardamom oil, black seed oil, and olive oil. The goal was to determine the optimal formulation for stable microemulsions and assess their potential as innovative drug delivery systems for the antidiabetic drug repaglinide.

Methods: Initial phase diagrams were constructed to identify the optimal ratios of oil, water, surfactant (Tween 80), and cosurfactant (ethanol) for producing stable microemulsions. The physical attributes of the resulting formulations, such as droplet size, zeta potential, and morphology, were characterized using transmission electron microscopy. Drug release profiles of microemulsions containing repaglinide were evaluated using the dialysis method. Moreover, vivo studies were conducted to assess the therapeutic efficacy of cardamom oil microemulsions compared to standard commercial repaglinide formulations.

Results: Microemulsions exhibited suitable properties with optimal particle size, well-defined spherical droplets, and optimized zeta potential. Drug release studies indicated that cardamom oil-based microemulsions demonstrated superior release characteristics, providing a more sustained and controlled release of repaglinide compared to microemulsions containing black seed or olive oil. In vivo studies revealed a significant improvement in antidiabetic outcomes with cardamom oil microemulsions over standard commercial repaglinide formulations. The enhanced efficacy was attributed to improved bioavailability and the controlled release properties of the drug.

Conclusion: This research underscores the potential of cardamom oil-based microemulsions as effective antidiabetic drug delivery systems. With superior physicochemical properties and controlled release profiles, they promise innovative treatment options for diabetes, potentially improving therapeutic outcomes for patients.

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研究目的本研究旨在评估用豆蔻油、黑籽油和橄榄油配制的微乳剂的抗糖尿病疗效。目的是确定稳定微乳的最佳配方,并评估其作为抗糖尿病药物瑞格列奈的创新给药系统的潜力:方法:构建了初始相图,以确定油、水、表面活性剂(吐温 80)和共表面活性剂(乙醇)的最佳比例,从而生产出稳定的微乳剂。利用透射电子显微镜对所得制剂的物理属性(如液滴大小、zeta 电位和形态)进行了表征。使用透析法评估了含有瑞格列奈的微乳剂的药物释放曲线。此外,还进行了体内研究,以评估豆蔻油微乳剂与标准商用瑞格列奈制剂相比的疗效:结果:微乳剂表现出合适的特性,具有最佳粒度、清晰的球形液滴和优化的 zeta 电位。药物释放研究表明,与含有黑籽油或橄榄油的微乳剂相比,豆蔻油基微乳剂具有更优越的释放特性,能更持久、更可控地释放瑞格列奈。体内研究显示,与标准的商用瑞格列奈制剂相比,豆蔻油微乳剂的抗糖尿病效果显著提高。疗效的提高归因于生物利用率的提高和药物的控释特性:这项研究强调了豆蔻油基微乳剂作为有效的抗糖尿病给药系统的潜力。它们具有优异的理化特性和控释特性,有望成为治疗糖尿病的创新选择,从而改善患者的治疗效果。
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来源期刊
CiteScore
7.30
自引率
13.20%
发文量
367
审稿时长
33 days
期刊介绍: The Journal of Pharmaceutical Sciences will publish original research papers, original research notes, invited topical reviews (including Minireviews), and editorial commentary and news. The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals, including crystallization, lyophilization, chemical stability of drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology, and targeted drug delivery.
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