An Atlas of Gallium-68-fibroblast Activation Protein Inhibitor (FAPI) in Oncology and Nononcology Imaging.

IF 0.5 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Indian Journal of Nuclear Medicine Pub Date : 2024-09-01 Epub Date: 2025-01-25 DOI:10.4103/ijnm.ijnm_70_24

Shrikant Vasantrao Solav, Rajlaxmi Rangrao Jagtap, Shailendra V Savale

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Abstract

Fibroblast activation protein (FAP) is a quinoline-based membrane bound glycoprotein enzyme. It is not expressed in normal adult tissue except for the myometrium and sometimes in pancreas. The expression increases in inflammation and in cancer-associated fibroblasts. Gallium 68-FAP inhibitor (FAPI) is known to localize in various neoplasms by the virtue of their property of cancer-associated fibroblast activity. Fibroblasts are also known to be associated in inflammatory and infectious condition such as cholecystitis, pyelonephritis, and tuberculosis. Immunoglobulin G4 related disease (IgG4RD) is characterized by infiltration of various tissues with IgG4-rich lymphoplasmacytic fibrotic tissue and has been reported to express cancer-associated fibroblast. The time-tested molecule for cancer imaging F18-fluorode-oxyglucose requires 4-6 h of fasting state. Ga68-FAPI does not require fasting. This pictorial essay illustrates various entities, cancerous as well as noncancerous using Ga68-FAPI positron emission tomography computed tomography (PET CT) imaging.

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镓-68成纤维细胞活化蛋白抑制剂（FAPI）在肿瘤和非肿瘤成像中的图谱。

成纤维细胞活化蛋白（FAP）是一种基于喹啉的膜结合糖蛋白酶。除肌层外，在正常成人组织中不表达，有时也在胰腺中表达。在炎症和癌症相关的成纤维细胞中表达增加。镓68-FAP抑制剂（FAPI）由于其与癌症相关的成纤维细胞活性的特性，已知可定位于各种肿瘤。成纤维细胞也被认为与炎症和感染性疾病有关，如胆囊炎、肾盂肾炎和肺结核。免疫球蛋白G4相关疾病（IgG4RD）的特点是多种组织浸润富含igg4的淋巴浆细胞纤维化组织，并已报道表达癌症相关成纤维细胞。经过时间考验的癌症成像分子f18 -氟脱氧葡萄糖需要4-6小时的禁食状态。Ga68-FAPI不需要禁食。这篇图片文章说明了使用Ga68-FAPI正电子发射断层扫描计算机断层扫描（PET CT）成像的各种实体，癌性和非癌性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Indian Journal of Nuclear Medicine RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

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