Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics – 2024 update

IF 4.4 2区医学 Q1 NEUROSCIENCES Journal of Physiology-London Pub Date : 2025-03-08 DOI:10.1113/JP284741

Olujimi A. Ajijola, Tolga Aksu, Rishi Arora, Italo Biaggioni, Peng-Sheng Chen, Gaetano De Ferrari, Veronica Dusi, Marat Fudim, Jeffrey J. Goldberger, Alexander L. Green, Neil Herring, Sahib S. Khalsa, Rajesh Kumar, Edward Lakatta, Reena Mehra, Christian Meyer, Sunny Po, Stavros Stavrakis, Virend K. Somers, Alex Y. Tan, Miguel Valderrabano, Kalyanam Shivkumar

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Abstract

The intricate role of the autonomic nervous system (ANS) in regulating cardiac physiology has long been recognized. Aberrant function of the ANS is central to the pathophysiology of cardiovascular diseases. It stands to reason, therefore, that neuroscience-based cardiovascular therapeutics hold great promise in the treatment of cardiovascular diseases in humans. A decade after the inaugural edition, this White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology and pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.

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临床神经心脏病学：定义基于神经科学的心血管疗法的价值 - 2024 年更新。

自主神经系统（ANS）在调节心脏生理中的复杂作用早已被认识到。ANS的异常功能是心血管疾病病理生理学的核心。因此，基于神经科学的心血管疗法在治疗人类心血管疾病方面具有很大的前景，这是理所当然的。在创刊十年后，本白皮书回顾了人类心脏神经解剖学、特定疾病条件下的神经生理学和病理生理学、自主神经测试、风险分层和缓解心血管疾病进展的神经调节策略的现状。

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来源期刊

Journal of Physiology-London 医学-神经科学

CiteScore

9.70

自引率

7.30%

发文量

817

审稿时长

2 months

期刊介绍： The Journal of Physiology publishes full-length original Research Papers and Techniques for Physiology, which are short papers aimed at disseminating new techniques for physiological research. Articles solicited by the Editorial Board include Perspectives, Symposium Reports and Topical Reviews, which highlight areas of special physiological interest. CrossTalk articles are short editorial-style invited articles framing a debate between experts in the field on controversial topics. Letters to the Editor and Journal Club articles are also published. All categories of papers are subjected to peer reivew. The Journal of Physiology welcomes submitted research papers in all areas of physiology. Authors should present original work that illustrates new physiological principles or mechanisms. Papers on work at the molecular level, at the level of the cell membrane, single cells, tissues or organs and on systems physiology are all acceptable. Theoretical papers and papers that use computational models to further our understanding of physiological processes will be considered if based on experimentally derived data and if the hypothesis advanced is directly amenable to experimental testing. While emphasis is on human and mammalian physiology, work on lower vertebrate or invertebrate preparations may be suitable if it furthers the understanding of the functioning of other organisms including mammals.