Anticancer potential of Bellardia trixago quantum dots: Cytotoxic effects on various cancer cell lines

IF 4.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Bioorganic Chemistry Pub Date : 2025-05-01 Epub Date: 2025-03-08 DOI:10.1016/j.bioorg.2025.108340

Erdi Can Aytar , Zeynep Betul Sarı , Muhammet Emin Sarı , Alper Durmaz , Emine Incilay Torunoğlu , Abidin Gümrükçüoğlu , Gamze Demirel

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Abstract

This study investigates the synthesis, characterization, and anticancer effects of carbon quantum dots (CQDs) derived from Bellardia trixago. The CQDs were analyzed using Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and X-ray Photoelectron Spectroscopy (XPS). TEM results revealed that the CQDs have a spherical morphology and exhibit a layered structure. XRD analysis showed a graphite-like crystalline structure, while FTIR and XPS studies confirmed the presence of OH, CC, and CO functional groups on the surface. The biological activity of CQDs demonstrated selective cytotoxicity, inducing significant cell death in cancer cells while exhibiting low toxicity in healthy cells. More pronounced morphological changes were observed in HEp-2 and SaOS-2 cells, while HEK-293 cells showed negligible changes. These findings suggest that quantum dots could serve as a potential alternative for cancer treatment.

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贝拉迪亚量子点的抗癌潜力：对多种癌细胞系的细胞毒作用

本研究研究了贝拉迪亚碳量子点（CQDs）的合成、表征及其抗癌作用。采用透射电镜（TEM）、x射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和x射线光电子能谱（XPS）对CQDs进行了分析。透射电镜结果表明，CQDs呈球形，呈层状结构。XRD分析显示为石墨状晶体结构，FTIR和XPS研究证实表面存在OH、CC和CO官能团。CQDs的生物活性表现出选择性的细胞毒性，在癌细胞中诱导显著的细胞死亡，而在健康细胞中表现出低毒性。HEp-2和SaOS-2细胞的形态学变化更为明显，而HEK-293细胞的形态学变化可以忽略不计。这些发现表明量子点可以作为癌症治疗的潜在替代方案。

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来源期刊

Bioorganic Chemistry 生物-生化与分子生物学

CiteScore

9.70

自引率

3.90%

发文量

679

审稿时长

31 days

期刊介绍： Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. The scope of the journal covers a range of topics at the organic chemistry-biology interface, including: enzyme catalysis, biotransformation and enzyme inhibition; nucleic acids chemistry; medicinal chemistry; natural product chemistry, natural product synthesis and natural product biosynthesis; antimicrobial agents; lipid and peptide chemistry; biophysical chemistry; biological probes; bio-orthogonal chemistry and biomimetic chemistry. For manuscripts dealing with synthetic bioactive compounds, the Journal requires that the molecular target of the compounds described must be known, and must be demonstrated experimentally in the manuscript. For studies involving natural products, if the molecular target is unknown, some data beyond simple cell-based toxicity studies to provide insight into the mechanism of action is required. Studies supported by molecular docking are welcome, but must be supported by experimental data. The Journal does not consider manuscripts that are purely theoretical or computational in nature. The Journal publishes regular articles, short communications and reviews. Reviews are normally invited by Editors or Editorial Board members. Authors of unsolicited reviews should first contact an Editor or Editorial Board member to determine whether the proposed article is within the scope of the Journal.