Early-onset Kleine-Levin syndrome in adolescent: A case report and review of literature

Abstract

Kleine-Levin syndrome (KLS) is an uncommon recurrent-remitting sleep disorder characterized by recurrent hypersomnia, compulsive eating, hypersexuality, and behavioral/psychiatric disturbances. Patients typically experience recurrent episodes, with normal cognitive function, behavior, and mood between episodes. Early-onset KLS cases in adolescents often involve frequent episodes alongside mood and behavioral abnormalities, leading to potential misdiagnosis. Thus, we provide a comprehensive overview of the patient's medical history, investigation, differential diagnoses, and treatment for a male adolescent with KLS. Additionally, we include a literature review to contribute to future research on KLS cases.